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Beneficial effects of L-NMMA in hyperdynamic endotoxic sepsis?

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Conclusion

Despite restoration of global hemodynamics, there was no beneficial effect of NO inhibition on the parameters of regional perfusion and oxygenation. Similar to septic mice, L-NMMA attenuated vascular leakage as suggested by significantly reduced formation of ascites.

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References

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Authors and Affiliations

  1. Universitätsklinik für Anästhesiologie, Klinikum der Universität, D-89075, Ulm

    Santak B, Handschuh T, Adler J, Iber T, Vassilev D, Georgieff M & Radermacher P

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  1. Santak B
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  2. Handschuh T
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  3. Adler J
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  4. Iber T
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  5. Vassilev D
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  6. Georgieff M
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  7. Radermacher P
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Supported by the Deutscher Akademischer Austauschdienst

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Santak, B., Handschuh, T., Adler, J. et al. Beneficial effects of L-NMMA in hyperdynamic endotoxic sepsis?. Intensive Care Med 22 (Suppl 1), S23 (1996). https://doi.org/10.1007/BF01921197

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  • DOI: https://doi.org/10.1007/BF01921197

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