Abstract
Since rare cases of sex chromosome anomalies such as XXX and XXY were observed in the offspring of our XO breeder mice, we performed a cytogenetic analysis of metaphase II oocytes of XO mice to determine whether any changes in chromosomal configurations occur. We found a significantly increased incidence of unpartnered single chromatids in metaphase II oocytes of XO mice. Such single chromatids may contribute to embryonic aneuploidy. In addition, the tendency of the X-chromosome to segregate non-randomly to the oocyte rather than to the polar body was confirmed.
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Sakurada, K., Omoe, K. & Endo, A. Increased incidence of unpartnered single chromatids in metaphase II oocytes in 39,X(XO) mice. Experientia 50, 502–505 (1994). https://doi.org/10.1007/BF01920758
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DOI: https://doi.org/10.1007/BF01920758