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Increased incidence of unpartnered single chromatids in metaphase II oocytes in 39,X(XO) mice

Experientia volume 50, pages 502–505 (1994)Cite this article

Abstract

Since rare cases of sex chromosome anomalies such as XXX and XXY were observed in the offspring of our XO breeder mice, we performed a cytogenetic analysis of metaphase II oocytes of XO mice to determine whether any changes in chromosomal configurations occur. We found a significantly increased incidence of unpartnered single chromatids in metaphase II oocytes of XO mice. Such single chromatids may contribute to embryonic aneuploidy. In addition, the tendency of the X-chromosome to segregate non-randomly to the oocyte rather than to the polar body was confirmed.

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Affiliations

  1. Department of Hygiene and Preventive Medicine, Yamagata University School of Medicine, 990-23, Yamagata, (Japan)

    K. Sakurada, K. Omoe & A. Endo

Authors
  1. K. Sakurada
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  2. K. Omoe
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  3. A. Endo
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Sakurada, K., Omoe, K. & Endo, A. Increased incidence of unpartnered single chromatids in metaphase II oocytes in 39,X(XO) mice. Experientia 50, 502–505 (1994). https://doi.org/10.1007/BF01920758

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  • DOI: https://doi.org/10.1007/BF01920758

Key words

  • XO mice
  • metaphase II oocyte
  • single chromatid
  • non-random segregation of the X-chromosome