Abstract
The aim of the present study was to see if L-arginine, which induces insulin release and is a precursor of the endothelial-derived relaxing factor nitric oxide, affects whole pancreatic and/or islet blood flow. For this purpose, anesthetized male Sprague-Dawley rats were injected intravenously with either saline or L-arginine (25, 100 or 250 mg/kg body weight). All doses of arginine caused a slight increase in blood glucose concentration, while the highest dose (250 mg/kg body weight) also increased insulin concentration. However, no changes in either mean arterial blood pressure, whole pancreatic or islet blood flow could be discerned with any of the doses of arginine used. It is concluded that insulin release is not necessarily associated with an increased islet blood perfusion.
Similar content being viewed by others
References
Bonner-Weir, S., Diabetes37 (1988) 616.
Bonner-Weir, S., in: The pancreas. Biology, Pathobiology, and Disease; 2nd ed. pp. 759–768. Eds V. L. diMagno, J. D. Gardner, E. Lebenthal, H. A. Reber, and G. A. Scheele. Raven Press Ltd, New York (USA) 1993.
Jansson, L., and Hellerström, C., Am. J. Physiol.251 (1986) E644.
Jansson, L., Diabetes Metabolism Reviews10 (1994) 407.
Svensson, A. M., Östenson, C.-G., Sandler, S., Efendic, S., and Jansson, L., Endocrinology135 (1994) 849.
Blachier, F., Leclerq-Meyer, V., Marchand, J., Woussen-Colle, M.-C., Mathias, P. C. F., Sener, A., and Malaisse, W. J., Biochim. biophys. Acta113 (1989) 144.
Palmer, R. M. J., Ashton, D. S., and Moncada, S., Nature, Lond.333 (1988) 664.
Moncada, S., Acta physiol. scand.145 (1992) 201.
Moncada, S., Palmer, R. M. J., and Higgs, E. A., Pharmacol. Rev.43 (1991) 109.
Jansson, L., and Hellerström, C., Diabetologia25 (1983) 45.
Jansson, L., and Hellerström, C., Acta physiol. scand.113 (1981) 371.
Heding, L. G., Diabetologia8 (1968) 260.
Floyd, J. C., Fajans, S. S., Conn, J. W., Knopf, R. F., and Rull, J., J. clin. Invest.45 (1966) 1487.
Jansson, L., Pancreas3 (1988) 409.
Jansson, L., Acta physiol. scand.124 (1985) 223.
Jansson, L., Eizirik, D. L., and Sandler, S., Eur. J. Pharmacol.161 (1989) 79.
Jun, T., and Wennmalm, Å., Acta physiol. scand.152 (1994) 385.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Svensson, A.M., Jansson, L. L-arginine and pancreatic islet blood flow in anesthetized rats. Experientia 52, 239–241 (1996). https://doi.org/10.1007/BF01920714
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF01920714