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Lymphopenia and lymphocyte transformation in alcoholics

Experientia volume 35, pages 268–269 (1979)Cite this article

Summary

The basis of peripheral blood lymphopenia observed in patients with chronic alcoholism and liver disease was investigated by examining the effect of sera of these patients on in vitro transformation of normal human peripheral blood lymphocytes. A positive correlation was demonstrated between the serum inhibition of phytohaemagglutinin- and pokeweed mitogen-induced transformation and the degree of lymphopenia. Thus serum factors may contribute to the observed lymphopenia by inhibiting lymphocyte production in vivo.

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Author information

Affiliations

  1. Monash University Department of Medicine, Alfred Hospital, 3181, Prahran, Victoria, Australia

    G. P. Young, M. B. Van der Weyden, I. S. Rose & F. J. Dudley

Authors
  1. G. P. Young
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  2. M. B. Van der Weyden
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  3. I. S. Rose
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  4. F. J. Dudley
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Additional information

This study was supported by grants from the National Health and Medical Research Council of Australia, Royal Australasian College of Physicians and Alfred Hospital Henry Laurie Scholarship Fund.

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Young, G.P., Van der Weyden, M.B., Rose, I.S. et al. Lymphopenia and lymphocyte transformation in alcoholics. Experientia 35, 268–269 (1979). https://doi.org/10.1007/BF01920656

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  • DOI: https://doi.org/10.1007/BF01920656

Keywords

  • Liver Disease
  • Blood Lymphocyte
  • Peripheral Blood Lymphocyte
  • Human Peripheral Blood
  • Lymphopenia