Summary
Angiotensin converting enzyme activity was found to be significantly decreased in the isolated perfused lung from zinc-deficient rats when compared with that of controls. Addition of zinc ion to the superfusion medium did not cause a recovery in this decreased activity of the enzyme. It is postulated that zinc deficiency probably produces a structural change in the lung angiotensin converting enzyme.
Similar content being viewed by others
References
Y.S. Bakhle, Handbk exp. Pharmac.37, 41 (1974).
R.K. Türker and Z.S. Ercan, Arch. int. Physiol. Biochim.83, 845 (1975).
P.R.B. Caldwell, H.J. Seegal, K.C. Hsu, M. Das and R.L. Soffer, Science191, 1050 (1976).
J.W. Ryan, U.S. Ryan, D.R. Schultz, C. Whitaker, A. Chung and F.E. Dorer, Biochem. J.146, 497 (1975).
R. Igic, E.G. Erdös, H.S.J. Yeh, K. Sorrells and T. Nakajima, Circulation Res.31, suppl. II, 51 (1972).
A. Grandino and A.C.M. Paiva, Biochim. biophys. Acta364, 113 (1974).
R.L. Soffer, A. Rev. Biochem.45, 73 (1976).
H. Swenertun and L.S. Hurley, J. Nutr.95, 8 (1968).
R.K. Türker, Arch. int. Physiol. Biochim.81, 523 (1973).
D. Regoli and J.R. Vane, Br. J. Pharmac.23, 351 (1964).
A.S. Prasad, D. Oberleas, P. Wolf and J.P. Horwitz, J. clin. Invest.46, 549 (1967).
J.G. Reinhold and G.A. Kfoury, Am. J. clin. Nutr.22, 1250 (1969).
Author information
Authors and Affiliations
Additional information
This work is supported by a grant from Turkish Scientific and Technical Research Council (TAG-350).
Rights and permissions
About this article
Cite this article
Ercan, Z.S., Öner, G., Türker, R.K. et al. Zinc deficiency and lung converting enzyme activity in rats. Experientia 35, 215–216 (1979). https://doi.org/10.1007/BF01920624
Published:
Issue Date:
DOI: https://doi.org/10.1007/BF01920624