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Tetrapyrrole biosynthesis from 4,5-dioxovaleric acid inRhodopseudomonas spheroides

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Summary

Porphyrin biosynthesis from 4,5-dioxovaleric acid was studied in cell suspensions ofR. spheroides. The experiments show that 4,5-dioxovaleric acid is a far precursor of porphyrins through δ amino laevulinic acid formation in a transamination reaction involving also 1-alanine. It differs radically from the classical δ aminolaevulinic acid synthesis using glycine and succinyl CoA as substrates.

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Abbreviations

δ ALA:

δ aminolaevulinate acid

DVA:

4,5-dioxovaleric acid

References

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Author notes

  1. R. Couso

    Present address: Instituto de Investigaciones Bioquímicas, Obligado 2490, 1428, Buenos Aires, Argentina

Authors and Affiliations

  1. Universidad de Buenos Aires, Facultad de Ciencias Exactas y Naturales, Departamento de Química Biológica, Ciudad Universitaria, Buenos Aires, Argentina

    R. Couso, M. Dimitrijewits de Albani, G. A. Locascio & H. A. Tigier

  2. Comisión Nacional de la Energía Atómica, Buenos Aires, Argentina

    R. Couso, M. Dimitrijewits de Albani, G. A. Locascio & H. A. Tigier

  3. Departamento de Ciencias Biológicas, Campus Universitario, Universidad Nacional de Río Cuarto, 5800 Río, Cuarto, Córdoba, Argentina

    R. Couso, M. Dimitrijewits de Albani, G. A. Locascio & H. A. Tigier

Authors
  1. R. Couso
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  2. M. Dimitrijewits de Albani
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  3. G. A. Locascio
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  4. H. A. Tigier
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Additional information

Acknowledgments: The authors are indebted to Dr Rodolfo García for helpful discussions and criticisms. Special thanks are given to Dr Aldo Mitta and other members of the ‘Comisión Nacional de la Energía Atómica’ for their continuous help and support and for using their facilities in order to synthetise DVA.

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Couso, R., Dimitrijewits de Albani, M., Locascio, G.A. et al. Tetrapyrrole biosynthesis from 4,5-dioxovaleric acid inRhodopseudomonas spheroides. Experientia 35, 168–169 (1979). https://doi.org/10.1007/BF01920591

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  • DOI: https://doi.org/10.1007/BF01920591

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