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Inhibitory effect of taurine on decrease in the inotropic action of ouabain at high concentrations in isolated atria

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Summary

In vitro, taurine was shown to inhibit the decrease in the inotropic effect of ouabain at large doses in the normal and also low K+ medium in which this decrease in the inotropism of ouabain was facilitated. This inhibitory effect of taurine was, at least in part, due to the inhibition of the efflux of intracellular K+ in the isolated heart.

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References

  1. J. Awapara, J. biol. Chem.218, 571 (1956).

    Article  CAS  PubMed  Google Scholar 

  2. J. G. Jacobsen and L. H. Smith, Jr, Physiol. Rev.48, 424 (1968).

    Article  CAS  PubMed  Google Scholar 

  3. J. J. Kocsis, V. J. Kostos and S. I. Baskin, in: Taurine, p. 145. Ed. R. Huxtable and A. Barbeau. Raven Press, New York 1976.

    Google Scholar 

  4. D. S. Grosso and R. Bressler, Biochem. Pharmac.25, 2227 (1976).

    Article  CAS  Google Scholar 

  5. W. O. Read and J. D. Welty, J. Pharmac. exp. Ther.139, 283 (1963).

    CAS  Google Scholar 

  6. S. Fujimoto and H. Iwata, Folia pharmac. jap.71, 53 (1975). (in Japanese).

    Article  CAS  Google Scholar 

  7. S. Fujimoto and H. Iwata, Jap. J. Pharmac.26, 105 (1976).

    Article  CAS  Google Scholar 

  8. J. D. Welty and W. O. Read J. Pharmac. exp. Ther.144, 110 (1964).

    CAS  Google Scholar 

  9. T. Akera, D. Ku and T. M. Brody, in: Taurine, p. 121. Ed. R. Huxtable and A. Barbeau, Raven Press, New York 1976.

    Google Scholar 

  10. J. Dietrich and J. Diacono, Life Sci.10, 499 (1971).

    Article  CAS  Google Scholar 

  11. A. Guidotti, D. Badiani and A. Giotti, Pharmac. Res. Commun.3, 29 (1971).

    Article  CAS  Google Scholar 

  12. H. Iwata and S. Fujimoto, Experientia32, 1559 (1976).

    Article  CAS  PubMed  Google Scholar 

  13. P. Dolara, A. Agresti, A. Giotti and G. Pasquini, Eur. J. Pharmac.24, 352 (1973).

    Article  CAS  Google Scholar 

  14. S. Dutta and B. H. Marks, J. Pharmac. exp. Ther.170, 318 (1966).

    Google Scholar 

  15. A. F. Lyon and A. C. degraff, Am. Heart J.73, 710 (1967).

    Article  CAS  PubMed  Google Scholar 

  16. B. B. Brodie, J. Axelrod, R. Soberman and B. B. Levy, J. biol. Chem.179, 25 (1949).

    Article  CAS  PubMed  Google Scholar 

  17. G. Ross and R. Mokotoff, J. biol. Chem.190 659 (1951).

    Article  CAS  PubMed  Google Scholar 

  18. R. Huxtable, in: Taurine, p. 99. Ed. R. Huxtable and A. Barbeau, Raven Press, New York 1976.

    Google Scholar 

  19. K. S. Lee, M. R. Shin, D. H. Kang and K. K. Chen, Biochem. Pharmac.19, 1055 (1970).

    Article  CAS  Google Scholar 

  20. R. Huxtable and R. Bressler, Biochim. biophys. Acta323, 573 (1973).

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Pharmacology, Nagoya City University Medical School, Kawasumi, Mizuho-ku, 467, Nagoya, Japan

    S. Fujimoto

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  1. S. Fujimoto
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Fujimoto, S. Inhibitory effect of taurine on decrease in the inotropic action of ouabain at high concentrations in isolated atria. Experientia 33, 1350–1352 (1977). https://doi.org/10.1007/BF01920175

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  • DOI: https://doi.org/10.1007/BF01920175

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