Skip to main content
SpringerLink
Log in

A low molecular weight glycosaminoglycan from the human aorta

  • Specialia Chimica, Biochimica
  • Published:
Experientia Aims and scope Submit manuscript

Summary

A low mol.wt, dialyzable glycosaminoglycan was isolated from human aorta and was found to be homogeneous on 2 dimensional electrophoresis. As judged by its electrophoretic mobilities and its hydrolysis by chondroitin sulfatase ABC, it was concluded that this hitherto unknown glycosaminoglycan is an oversulfated chondroitin sulfate.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. R. L. Stevens, M. Colombo, J. J. Gonzales, W. Hollander and K. Schmid, J. clin. Invest.58, 470 (1976).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. R. Hata and Y. Nagai, Analyt. Biochem.45, 462 (1972).

    Article  CAS  PubMed  Google Scholar 

  3. The authors are grateful to Dr T. Okuyama, Seikagaku Kogyo Co., Tokyo, Japan, for the generous gift of chondroitinase ABC and to Dr M. B. Mathews, University of Chicago, for standard glycosaminoglycans.

  4. The weight of this fraction was too small for analysis.

  5. T. Bitter and H. Muir, Analyt. Biochem.4, 330 (1962).

    Article  CAS  PubMed  Google Scholar 

  6. In control experiments carried out to assess the effect of papain and of incubation at pH 1–2 on high mol.wt GAGs, it could be established that to dialyzable mucopolysaccharides were formed.

Download references

Author information

Author notes

  1. J. P. Binette

    Present address: Veterans Administration Hospital, 14215, Buffalo, N.Y., USA

Authors and Affiliations

  1. Department of Biochemistry, Boston University School of Medicine, Boston University Medical Center, 02118, Boston, Massachusetts, USA

    R. L. Stevens, J. P. Binette, A. Kimura, R. B. Nimberg & K. Schmid

  2. Department of Medicine, State University of New York, Buffalo

    J. P. Binette

Authors
  1. R. L. Stevens
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. J. P. Binette
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. A. Kimura
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. R. B. Nimberg
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. K. Schmid
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

This study was supported by grants from the National Institutes of Health (GM-10374, HL-13262), U.S. Public Health Service.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Stevens, R.L., Binette, J.P., Kimura, A. et al. A low molecular weight glycosaminoglycan from the human aorta. Experientia 33, 1282–1283 (1977). https://doi.org/10.1007/BF01920134

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01920134

Keywords

Search

Navigation