Effect of aldosterone and methylprednisolone on cardiac NaK-ATPase
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Aldosterone (15 μg BID) and methylprednisolone (8 mg QD) administration to female guinea-pigs augmented both the total and the specific activity of NaK-ATPase but not the activity of adenylate cyclase in the cardiac sarcolemma. The rise in NaK-ATPase was due to increase in the number of enzyme molecules; catalytic activity and ouabain-sensitivity of individual molecules did not change.
KeywordsEnzyme Catalytic Activity Aldosterone Methylprednisolone Adenylate Cyclase