Summary
4 types of riboflavine antagonists have broad-spectrum activity in poultry coccidiosis. 5-Deazariboflavine is most effective. 10-Benzyl analogs of riboflavine control intestinal species of coccidia.
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References
R. E. Lux, Antibiot. Chemother.4, 971 (1954).
E. F. Rogers, R. L. Clark, H. J. Becker, A. A. Pessolano, W. J. Leanza, E. C. McManus, F. J. Andriuli and A. C. Cuckler, Proc. Soc. exp. Biol. Med.117, 488 (1964).
E. F. Rogers, R. L. Clark, A. A. Pessolano, H. J. Becker, W. J. Leanza, L. H. Sarett, A. C. Cuckler, E. C. McManus, M. Garzillo, C. Malanga, W. H. Ott, A. M. Dickinson and A. Van Iderstine, J. Am. Chem. Soc.82, 2974 (1960); E. F. Rogers, Meth. Enzym.18a, 245 (1970).
S. J. Ball, E. W. Warren and E. W. Parnell, Nature208, 397 (1965).
E. C. McManus and E. F. Rogers, Fed. Proc.28, 390 (1969).
Y. Morisawa, M. Kataoka, T. Watanabe, N. Kitano and T. Matsuzawa, J. med. Chem.17, 1083 (1974).
E. W. Warren, M. Sci. Thesis, University of London (1966); Parasitology58, 137 (1968).
S. J. Ball and E. W. Warren, Vet. Rec.80, 581 (1967).
J. F. Ryley and R. G. Wilson, J. Parasit.58, 664 (1972).
J. P. Lambooy, in: Riboflavin, p. 303. Ed. R. S. Rivlin. Plenum Press, New York, N. Y. 1975.
C. H. Shunk, F. R. Koniuszy and K. Folkers, J. Am. Chem. Soc.74, 4251 (1952).
D. E. O'Brien, L. T. Weinstock and C. C. Cheng, Chem. Ind., Lond.1967, 2044; J. Heterocycl. Chem.7, 99 (1970).
For these and other biological data cited herein, we are greatly indebted to Drs George Olson, Edward C. McManus, Brinton M. Miller and Ching Chung Wang of these laboratories.
D. E. Edmondson, B. Barman and G. Tollin, Biochemistry11, 1133 (1972).
M. S. Jorns and L. B. Hersh, J. Am. Chem. Soc.96, 4012 (1974).
J. Fisher and C. Walsh, J. Am. Chem. Soc.96, 4345 (1974).
B. A. Averill, A. Schonbrunn and R. H. Abeles, J. biol. Chem.250, 1603 (1975).
M. S. Jorns and L. B. Hersh, J. biol. Chem.250, 3620, 8728 (1975).
T. H. Cromartie and C. T. Walsh, J. biol. Chem.251, 329 (1976).
L. B. Hersh, M. S. Jorns, J. Peterson and M. Currie, J. Am. Chem. Soc.98, 865 (1976).
M. S. Jorns and L. B. Hersh, J. biol. Chem.251, 4782 (1976).
R. Spencer, J. Fisher and C. T. Walsh, Biochemistry15, 1043 (1976).
J. Fisher, R. Spencer and C. T. Walsh, Biochemistry15, 1054 (1976).
C. H. Shunk, J. B. Lavigne and K. Folkers, J. Am. Chem. Soc.77, 240 (1955).
K. Yagi, Meth. Enzym.18b, 465 (1971).
H. Y. K. Chuang, D. R. Patek and L. Hellerman, J. biol. Chem.249, 2384 (1974).
V. M. Berezovskii, L. S. Tul'chinskaya and N. A. Polyakova, Zh. obshch. Khim.35, 673 (1965).
S. Otani, M. Takatsu, M. Nakano, S. Kasai, R. Miura and K. Matsui, J. Antibiot.27, 88 (1974).
S. Kasai, R. Miura and K. Matsui, Bull. Chem. Soc. Jap.48, 2877 (1975).
These values are in good agreement with those reported by Kasai et al.20.
E. E. Haley and J. P. Lambooy, J. Am. Chem. Soc.76, 5093 (1954).
A. Dornow and E.-H. Rohe, Chem. Ber.93, 1093 (1960).
M. Israel and N. Mohammad, J. Hetercycl. Chem.10, 209 (1973). Reaction mixture heated for 9 h.
E. Ziegler, R. Salvador and T. Kappe, Mh. Chem.93, 1376 (1962).
N. J. Leonard and R. F. Lambert, J. org. Chem.34, 3420 (1969).
All new compounds gave correct elemental analyes.
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Graham, D.W., Brown, J.E., Ashton, W.T. et al. Anticoccidial riboflavine antagonists. Experientia 33, 1274–1276 (1977). https://doi.org/10.1007/BF01920129
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DOI: https://doi.org/10.1007/BF01920129