, Volume 32, Issue 6, pp 725–727 | Cite as

Sur l'inversion de l'action hypertensive de la prostaglandine F, chez le rat

  • J. Damas

Reversal of the pressor effect of PGF in the rat


In normal rats, prostaglandin F is a potent vasoconstrictor. The corresponding systemic hypertension is progressively attenuated by tachyphylaxis, revealing a longlasting fall of blood pressure. Tachyphylaxis is accelerated by previous injection of arachidonic acid and bradykinin. The vasodepressive activity of PGF is inhibited by indomethacin.


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Copyright information

© Birkhäuser Verlag 1976

Authors and Affiliations

  • J. Damas
    • 1
  1. 1.Institut Léon Frédéric, Physiologie humaine, normale et pathologiueUniversité de LiègeLiège(Belgium)

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