, Volume 32, Issue 6, pp 691–693 | Cite as

Abnormally soluble collagen produced in fibroblasts cultures

  • G. Francis
  • Patricia V. Donnelly
  • N. di Ferrante


Abnormally soluble collagen is synthesized in vitro not only by skin fibroblasts of Marfan patients but also by those of patients with Ehlers-Danlos type V and cutis laxa. The excessive solubility of collagen is corrected by the addition to the culture medium of a synthetic flavonoid, (+)-catechin.


Collagen Flavonoid Catechin Type Versus Skin Fibroblast 


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  1. 2.
    R. E. Priest, J. F. Moinuddin andJ. H. Priest, Nature, Lond.245, 264 (1973).Google Scholar
  2. 3.
    N. Di Ferrante, R. D. Leachman, P. Angelini, P. V. Donnelly, G. Francis, A. Almazan andG. Segni, Connect. Tiss. Res.3, 49 (1975).Google Scholar
  3. 4.
    H. Schlebusch andD. Kern, Angiology9, 248 (1972).Google Scholar
  4. 5.
    J. Singh, P. V. Donnelly, N. di Ferrante, B. L. Nichols andP. Niebes, J. Lab. clin. Med.84, 438 (1974).PubMedGoogle Scholar
  5. 6.
    B. R. Switzer andG. K. Sumner, Analyt. Biochem.39, 487 (1971).CrossRefPubMedGoogle Scholar
  6. 7.
    M. Macek, J. Hurygh, M. Chvapil andV. Kadlecova, Humangenetik3, 87 (1966).CrossRefPubMedGoogle Scholar
  7. 8.
    V. A. McKusick,Heritable Disorders of Connective Tissue (Mosby, St. Louis 1972).Google Scholar
  8. 9.
    G. Cetta, G. Pallavicini, A. Calatroni, G. Fossati andA. A. Castellani, IV European Symposium on Connective Tissue Research, Padova, Italy (1974).Google Scholar

Copyright information

© Birkhäuser Verlag 1976

Authors and Affiliations

  • G. Francis
    • 1
  • Patricia V. Donnelly
    • 1
  • N. di Ferrante
    • 1
  1. 1.Laboratories of Connective Tissue Research, Department of BiochemistryBaylor College of MedicineHoustonUSA

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