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Lathyrogenic activity of 2 (2-cyanoethyl)-3-isoxazolin-5-one fromLathyrus odoratus seedlings

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  • Chimica, Biochimica
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Résumé

L'administration au rat de 2(2-cyanoethyl)-3-isoxazolin-5-one (comp. VIII), un composant des jets deLathyrus odoratus, cause un retardement de la croissance ainsi que des anomalies du squelette, caractéristiques de la substance lathyrogène β-aminopropionitrile (BAPN). L'excrétion du BAPN suggère que l'activité lathyrogène de VIII est dûe à la libération du BAPN in situ.

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Authors and Affiliations

  1. Laboratory of Biochemistry, Faculty of Agronomic Sciences, State University, B-9000, Ghent, Belgium

    L. van Rompuy, F. Lambein, R. Van Parijs & C. Ressler

  2. Division of Protein Chemistry, Institute for Muscle Disease, Inc., 10021, New York, USA

    L. van Rompuy, F. Lambein, R. Van Parijs & C. Ressler

  3. Department of Biochemistry, Cornell University Medical College, 10021, New York, New York, USA

    L. van Rompuy, F. Lambein, R. Van Parijs & C. Ressler

Authors
  1. L. van Rompuy
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  2. F. Lambein
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  3. R. Van Parijs
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  4. C. Ressler
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Additional information

This work was aided by Nationaal Fonds Voor Wetenschappelijk Onderzoek, Belgium, U. S. Public Health Service Grant No. NS 04316, and by Muscular Dystrophy Associations of America. The authors thank Dr.K. S. Singh for assistance, Mr.M. Lukacovic for amino acid analyses, and Dr.J. Kaye, Hospital for Special Surgery, N. Y., for the X-rays and their interpretation.

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van Rompuy, L., Lambein, F., Van Parijs, R. et al. Lathyrogenic activity of 2 (2-cyanoethyl)-3-isoxazolin-5-one fromLathyrus odoratus seedlings. Experientia 30, 1379–1380 (1974). https://doi.org/10.1007/BF01919644

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  • DOI: https://doi.org/10.1007/BF01919644

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