Skip to main content
SpringerLink
Log in

Mismatch repair as an important source of new mutations in non-dividing cells

  • Research Articles
  • Published:
Cellular and Molecular Life Sciences Aims and scope Submit manuscript

Abstract

This paper describes a mechanism which permits somatic cells to generate random mutations in the complete absence of cell proliferation. Knowledge of the existence of this mechanism should provide us with the basis for a better understanding of a number of important biological phenomena, and in particular may help to explain the origins of many human cancers.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Modrich, P., A. Rev. Genet25 (1991) 229.

    Article  CAS  Google Scholar 

  2. Modrich, P., Phil. Trans. R. Soc. Lond. B347 (1995) 89.

    Article  CAS  Google Scholar 

  3. Kunkel, T. A., Meyer, R. R., and Loeb, L. A., Proc. natl Acad. Sci. USA76 (1979) 633.

    Article  Google Scholar 

  4. Loeb, L., Cancer Res.54 (1994) 5059.

    CAS  PubMed  Google Scholar 

  5. Nevers, P., and Spatz, H.-C., Molec. gen. Genet.139 (1975) 233.

    Article  CAS  PubMed  Google Scholar 

  6. Schaaper, R. M., and Dunn, R. L., Proc. natl Acad. Sci. USA84 (1987) 6220.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Fishel, R., Lescoe, M. K., Rao, M. R. S., Copeland, N. G., Jenkins, N. A., Garber, J., Kane, M., and Kolodner, R., Cell75 (1993) 1027.

    Article  CAS  PubMed  Google Scholar 

  8. Bronner, C. E., Baker, S. M., Morrison, P. T., Warren, G., Lescoe, M. K., Kane, M., Earabinoc, C., Lipford, J., Lindblom, A., Tannergord, P., Bollag, R. J., Godwin, A. R., Ward, D. C., Nordenskjold, M., Fishel, R., Kolodner, R., and Liskay, R. M., Nature, Lond.368 (1994) 258.

    Article  CAS  PubMed  Google Scholar 

  9. Strauss, B. S., Cancer Res.52 (1992) 249.

    CAS  PubMed  Google Scholar 

  10. Holliday, R., Genet. Res.6 (1964) 282.

    Article  Google Scholar 

  11. Walker, G. C., Microbiol. Rev.8 (1984) 60.

    Article  Google Scholar 

  12. Bridges, B. A., and Woodgate, R., Molec. gen. Genet.196 (1984) 364.

    Article  CAS  PubMed  Google Scholar 

  13. Saul, R. L., and Ames, B. N., Basic Life Sci.38 (1986) 529.

    CAS  PubMed  Google Scholar 

  14. Shapiro, J. A., Molec. gen. Genet.194 (1984) 79.

    Article  CAS  PubMed  Google Scholar 

  15. Cairns, J., Overbaugh, J. and Miller, S., Nature, Lond.335 (1988) 142.

    Article  CAS  PubMed  Google Scholar 

  16. Hall, B. G., Genetics126 (1990) 5.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  17. Loeb, L., Cancer Res.51 (1991) 3075.

    CAS  PubMed  Google Scholar 

  18. Cairns, J., Cancer: Science and Society. W. H. Freeman, San Francisco 1978.

    Google Scholar 

  19. Novick, A., and Szilard, L., Proc. natl Acad. Sci. USA36 (1950) 708.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  20. Ryan, F. J., Nakeda, D., and Schneider, M. J., Z. VererbLehre92 (1961) 38.

    CAS  Google Scholar 

  21. Holliday, R., Genet. Res.3 (1962) 472.

    Article  Google Scholar 

  22. Witkin, E. M., and Sicurella, N. A., J. molec. Biol.8 (1964) 610.

    Article  CAS  PubMed  Google Scholar 

  23. Rinehart, R. R., Mutat. Res.7 (1969) 417.

    Article  CAS  PubMed  Google Scholar 

  24. Eckardt, F., Teh, S., and Haynes, R. H., Genetics95 (1980) 63.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  25. Marinkovic, D., and Majraktari, I., Genetica77 (1988) 113.

    Article  CAS  PubMed  Google Scholar 

  26. Burnet, F. M., Intrinsic Mutagenesis: A Genetic Approach to Ageing, pp. 36–45. Medical and Technical Publishing, Lancaster 1974.

    Google Scholar 

  27. Martin, A. P. and Palumbi, S. R., Proc. natl Acad. Sci. USA90 (1992) 4087.

    Article  Google Scholar 

  28. MacPhee, D. G., Cytobios75 (1993) 69.

    CAS  PubMed  Google Scholar 

  29. Manser, T., Immunol. Today11 (1990) 305.

    Article  CAS  PubMed  Google Scholar 

  30. Berek, C., and Ziegner, M., Immunol. Today14 (1993) 400.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. School of Microbiology, Bundoora Campus, La Trobe University, 3083, Melbourne, Victoria, Australia

    D. G. MacPhee

Authors
  1. D. G. MacPhee
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

MacPhee, D.G. Mismatch repair as an important source of new mutations in non-dividing cells. Experientia 52, 357–363 (1996). https://doi.org/10.1007/BF01919541

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01919541

Key words

Search

Navigation