Abstract
The fractional saturation of hemoglobin with oxygen was plotted against P/P50 and the slope of the abscissa at 1 was calculated for 38 OEC data sets of human Hb A. There was a linear correlation between the slope and the Hill coefficient (nmax), and the slope was about one-forth that of nmax. This implies that the slope of the abscissa at 1 of Y vs P/P50 plot can provide information about the magnitude of cooperativity in hemoglobin oxygen binding.
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Kobayashi, M., Satoh, G. & Ishigaki, K. Sigmoid shape of the oxygen equilibrium curve and the P50 of human hemoglobin. Experientia 50, 705–707 (1994). https://doi.org/10.1007/BF01919366
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DOI: https://doi.org/10.1007/BF01919366