, Volume 48, Issue 10, pp 1013–1017 | Cite as

Juvenilizing effect of ecdysone mimic RH 5849 inGalleria mellonella larvae

  • M. Muszyńska-Pytel
  • P. Mikołajczyk
  • M. A. Pszczółkowski
  • B. Cymborowski
Research Articles


The response of the final instar larvae ofG. mellonella to topical application of the non-steroidal ecdysone mimic, RH 5849, was age-related as well as dose-dependent. In young final instar larvae, moderate doses of RH 5849 induced perfect supernumerary larval moults, but doses equal to and higher than 8.5 μg per larva caused premature formation of larval cuticle and were lethal. Application of RH 5849 significantly increased allatotropic activity of the brain, and also activated synthesis of juvenile hormone (JH) by the corpora cardiaca/corpora allata complex. Simultaneous application of RH 5849 and FMev, a potent inhibitor of JH synthesis, to young final instar larvae lowered the incidence of perfect supernumerary larval moults. We conclude that the effect of RH 5849 on the developmental programme inG. mellonella is mediated by the corpora allata.

Key words

Galleria mellonella ecdysone mimic RH 5849 juvenile hormone allatotropic activity corpora allata supernumerary larval moult juvenilizing effect 


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Copyright information

© Birkhäuser Verlag 1992

Authors and Affiliations

  • M. Muszyńska-Pytel
    • 1
  • P. Mikołajczyk
    • 1
  • M. A. Pszczółkowski
    • 1
  • B. Cymborowski
    • 1
  1. 1.Department of Invertebrate PhysiologyWarsaw UniversityWarszawaPoland

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