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The presence of free D-serine, D-alanine and D-proline in human plasma

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Abstract

Twelve neutral free amino acids, i. e., serine, threonine, glutamine, asparagine, alanine, proline, methionine, tyrosine, valine, leucine, isoleucine and phenylalanine, were surveyed for the presence of D-enantiomers in plasma samples from patients with renal diseases and from normal subjects. D-serine, D-alanine and D-proline were found in the patient's plasma. The highest concentrations (D/L ratio) of D-serine, D-alanine and D-proline were 0.2362, 0.2087 and 0.0986, respectively. The sum of the contents of the three D-amino acids in a plasma sample correlated with the serum creatinine level of the subject. No D-amino acid was shown to be present in the plasma proteins.

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Authors and Affiliations

  1. Department of Life Science, Himeji Institute of Technology, 2167 Shosha, 671-22, Himeji, Japan

    Y. Nagata

  2. Department of Biology, Faculty of Science, Osaka University, Osaka, Japan

    R. Masui

  3. Department of Biochemistry, Sapporo Medical College, Sapporo, Japan

    T. Akino

Authors
  1. Y. Nagata
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  2. R. Masui
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  3. T. Akino
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Nagata, Y., Masui, R. & Akino, T. The presence of free D-serine, D-alanine and D-proline in human plasma. Experientia 48, 986–988 (1992). https://doi.org/10.1007/BF01919147

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  • DOI: https://doi.org/10.1007/BF01919147

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