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Mechanoelectrical transduction, ion movement and water stasis in uromodulin

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Abstract

Mechanical movement of a column of the urinary glycoprotein uromodulin modulates an applied voltage. This change is a property of the glycoprotein and its interaction with the walls of the container and is related to its capacitance. The voltage modulation is not accompanied by changes in rotationally restricted water as has been reported for hyaluronic acid. Diffusion experiments with tritiated water also support the hypothesis that uromodulin acts as a water barrier, but allows ion movement.

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References

  1. Fletcher, A. P., McLaughlin, J. E., Ratcliffe, W. A., and Woods, O. A., Biochim. biophys. Acta214 (1970) 299.

    Article  CAS  PubMed  Google Scholar 

  2. Keutel, H. J., J. Histochem. Cytochem.13 (1966) 155.

    Article  Google Scholar 

  3. McKenzie, J. K., and McQueen, F. G., J. clin. Path.22 (1969) 333.

    Google Scholar 

  4. Schenk, E. A., Schwartz, R. H., and Lewis, R. A., Lab. Invest.25 (1971) 92.

    CAS  PubMed  Google Scholar 

  5. Sikri, K. L., Foster, C. L., Bloomfield, F. J., and Marshall, R. D., Biochem. J.181 (1979) 515.

    Article  Google Scholar 

  6. Burg, M. B., and Green, N., Am. J. Physiol.224 (1973) 659.

    Article  CAS  PubMed  Google Scholar 

  7. Rocha, A. S., and Kokko, J. P., J. clin. Invest.52 (1973) 612.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Lee, C. Y., McCammon, J. A., and Rossky, P. J., J. Chem. Phys.80 (1984) 4448.

    Article  CAS  Google Scholar 

  9. Hallenga, K., Grigera, J. R., and Berendsen, H. J. C., J. Phys. Chem.84 (1980) 2381.

    Article  CAS  Google Scholar 

  10. Grant, E. H., McClean, V. E. R., Nightingale, N. R. V., Sheppard, R. J., and Chapman, M. J., Bioelectromagnetics7 (1986) 151.

    Article  CAS  PubMed  Google Scholar 

  11. Barrett, T. W., Biochim. biophys. Acta385 (1975) 157.

    Article  CAS  PubMed  Google Scholar 

  12. Barrett, T. W., Physiol. Chem. Phys.8 (1976) 125.

    CAS  PubMed  Google Scholar 

  13. Jensen, C. E., Koefoed, J., and Vilstrup, T., Nature174 (1954) 1101.

    Article  CAS  Google Scholar 

  14. Christiansen, J. A., Acta otolaryng.57 (1964) 33.

    Article  CAS  PubMed  Google Scholar 

  15. Tamm, I., and Horsfall, F. J., Proc. Soc. exp. Biol. Med.74 (1950) 108.

    Article  CAS  Google Scholar 

  16. Tamm, I., and Horsfall, F. J., J. exp. Med.95 (1952) 71.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  17. Mascarenhas, S., in: Electrets. Ed. M. Perlam. The Electrochemical Society, Inc., New York 1973.

    Google Scholar 

  18. Barrett, T. W., Biosystems8 (1976) 103.

    Article  CAS  PubMed  Google Scholar 

  19. Bloomfield, F. J., Dunstan, D., Foster, C. L., Serafini-Cessi, F., and Marshall, R. D., Biochem. J.164 (1977) 41.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  20. Tamm, I., Bugher, J. C., and Horsfall, F. J., J. biol. Chem.212 (1955) 123.

    Article  Google Scholar 

  21. Maxfield, M., Biochim. biophys. Acta49 (1961) 548.

    Article  CAS  PubMed  Google Scholar 

  22. Ginetzinsky, A. G., Nature182 (1958) 1218.

    Article  CAS  PubMed  Google Scholar 

  23. Koefoed, J., and Knudsen, P. J., Proc. 1st int. Cong. Nephrol., Geneva 1960, p. 571.

  24. Pethig, R., Ferroelectrics86 (1988) 31.

    Article  CAS  Google Scholar 

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Mattey, M., Naftalin, L. Mechanoelectrical transduction, ion movement and water stasis in uromodulin. Experientia 48, 975–980 (1992). https://doi.org/10.1007/BF01919145

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