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Gastrin: Obligatory intermediate in the postprandial mobilization of gastric histamine in the rat

Experientia volume 33, pages 1541–1543 (1977)Cite this article

Summary

In unoperated fasted rats, feeding raised the serum gastrin concentration, reduced the gastric mucosal histamine content and activated the gastric histidine decarboxylase. The reduction of gastric histamine and activation of histidine decarboxylase was induced also by the injection of pentagastrin. In antrectomized rats, feeding failed to produce these effects. Injection of pentagastrin, however, still lowered gastric histamine and activated gastric histidine decarboxylase. Thus, antral gastrin seems to be an obligatory mediator of the postprandial activation of histidine decarboxylase and mobilization of histamine.

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References

  1. R. Håkanson and Ch. Owman, Life Sci.6, 759 (1967).

    PubMed  Google Scholar 

  2. R. Håkanson Ch. Owman, B. Sporrong and F. Sundler, Z. Zellforsch. mikrosk. Anat.122, 460 (1971).

    PubMed  Google Scholar 

  3. R. Håkanson, L.-I. Larsson, G. Liedberg, J. Oscarson, F. Sundler and J. Vang, J. Physiol.259, 785 (1976).

    PubMed  Google Scholar 

  4. R. Håkanson, J. H. Kroesen, G. Liedberg, J. Oscarson, J. F. Rehfeld and F. Stadil, J. Physiol.243, 483 (1974).

    PubMed  Google Scholar 

  5. G. Kahlson, E. Rosengren, D. Svahn and R. Thunberg, J. Physiol.174, 400 (1964).

    PubMed  Google Scholar 

  6. G. Kahlson, E. Rosengren and R. Thunberg, J. Physiol.190, 435 (1967).

    Google Scholar 

  7. L. R. Johnson, R. S. Jones, D. Aures and R. Håkanson, Am. J. Physiol.216, 1051 (1969).

    PubMed  Google Scholar 

  8. D. Aures, L. R. Johnson and L. Way, Am. J. Physiol.219, 214 (1970).

    PubMed  Google Scholar 

  9. R. Håkanson and G. Liedberg, Eur. J. Pharmac.12, 94 (1970).

    Google Scholar 

  10. R. Håkanson and G. Liedberg, Eur. J. Pharmac.18, 31 (1972).

    Google Scholar 

  11. F. Stadil and J. F. Rehfeld, Scand. J. Gastroenterol. suppl.9, 61 (1971).

    Google Scholar 

  12. R. Håkanson, L.-I. Larsson, G. Liedberg, J. F. Rehfeld and F. Sundler, J. Physiol.269, 643 (1977).

    PubMed  Google Scholar 

  13. R. Håkanson and G. Liedberg, Am. J. Physiol.221, 641 (1971).

    PubMed  Google Scholar 

Download references

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Affiliations

  1. Departments of Pharmacology and Surgery, University of Lund, Lund, Sweden

    R. Håkanson, J. Hedenbro, G. Liedberg, H. A. El Munshid & J. F. Rehfeld

  2. Institute of Medical Biochemistry, University of Aarhus, Aarhus, Denmark

    R. Håkanson, J. Hedenbro, G. Liedberg, H. A. El Munshid & J. F. Rehfeld

Authors
  1. R. Håkanson
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  2. J. Hedenbro
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  3. G. Liedberg
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  4. H. A. El Munshid
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  5. J. F. Rehfeld
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Additional information

Acknowledgments. Grant support from the Swedish and Danish Medical Research Councils (14P-4822, 04X-1007, 17X-4144 and 512-2540).

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Håkanson, R., Hedenbro, J., Liedberg, G. et al. Gastrin: Obligatory intermediate in the postprandial mobilization of gastric histamine in the rat. Experientia 33, 1541–1543 (1977). https://doi.org/10.1007/BF01918860

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  • DOI: https://doi.org/10.1007/BF01918860

Keywords

  • Histamine
  • Histidine
  • Serum Gastrin
  • Pentagastrin
  • Histamine Content