Experientia

, Volume 33, Issue 11, pp 1541–1543 | Cite as

Gastrin: Obligatory intermediate in the postprandial mobilization of gastric histamine in the rat

  • R. Håkanson
  • J. Hedenbro
  • G. Liedberg
  • H. A. El Munshid
  • J. F. Rehfeld
Endocrinologica

Summary

In unoperated fasted rats, feeding raised the serum gastrin concentration, reduced the gastric mucosal histamine content and activated the gastric histidine decarboxylase. The reduction of gastric histamine and activation of histidine decarboxylase was induced also by the injection of pentagastrin. In antrectomized rats, feeding failed to produce these effects. Injection of pentagastrin, however, still lowered gastric histamine and activated gastric histidine decarboxylase. Thus, antral gastrin seems to be an obligatory mediator of the postprandial activation of histidine decarboxylase and mobilization of histamine.

Keywords

Histamine Histidine Serum Gastrin Pentagastrin Histamine Content 

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Copyright information

© Experientia 1977

Authors and Affiliations

  • R. Håkanson
    • 1
    • 2
  • J. Hedenbro
    • 1
    • 2
  • G. Liedberg
    • 1
    • 2
  • H. A. El Munshid
    • 1
    • 2
  • J. F. Rehfeld
    • 1
    • 2
  1. 1.Departments of Pharmacology and SurgeryUniversity of LundLundSweden
  2. 2.Institute of Medical BiochemistryUniversity of AarhusAarhusDenmark

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