Advertisement

Experientia

, Volume 33, Issue 11, pp 1486–1487 | Cite as

Methadone and brain development

  • I. S. Zagon
  • Patricia J. McLaughlin
Pharmacologica

Summary

The effect of maternally administered methadone hydrochloride (5 mg/kg) on brain development of off-spring treated during gestation and/or lactation was studied in 21-day-old rats. Animals treated during gestation or lactation were the most severely affected, with reductions in brain weights (12% and 30%,respectively), and DNA values (50% and 34%, respectively) observed.

Keywords

Hydrochloride Brain Development Brain Weight 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 2.
    G. Blinick, R. Wallach, E. Jerez and B. Ackerman, Am. J. Obstet. Gynec.125, 135 (1976).PubMedGoogle Scholar
  2. 3.
    R. Ting, A. Keller and L. Finnegan, Proc. 2nd natl Drug Abuse Conf. (1975).Google Scholar
  3. 4.
    G. Wilson, Addict. Dis.2, 333 (1975).PubMedGoogle Scholar
  4. 5.
    W. F. Geber and L. C. Schramm, Am. J. Obstet. Gynec.123, 705 (1975).PubMedGoogle Scholar
  5. 6.
    A. Jurand, J. Embryol. expl Morph.30, 449 (1973).Google Scholar
  6. 7.
    M. Crofford and A. Smith, Science181, 947 (1973).PubMedGoogle Scholar
  7. 8.
    I. S. Zagon and P. J. McLaughlin, Biol. Neonate31, 271 (1977).PubMedGoogle Scholar
  8. 9.
    I. S. Zagon and P. J. McLaughlin, Expl Neurol.56, 538 (1977).Google Scholar
  9. 10.
    W. Schneider, J. biol. Chem.161, 293 (1945).Google Scholar
  10. 11.
    K. Burton, Biochem. J.62, 315 (1956).PubMedGoogle Scholar
  11. 12.
    J. Dobbing and J. Sands, Brain Res.17, 115 (1970).PubMedGoogle Scholar
  12. 13.
    J. Altman, in: Developmental Neurobiology, p. 197. Ed. W. A. Himwich. C. C. Thomas, Springfield, III. 1970.Google Scholar

Copyright information

© Experientia 1977

Authors and Affiliations

  • I. S. Zagon
    • 1
  • Patricia J. McLaughlin
    • 1
  1. 1.Department of AnatomyThe Milton S. Hershey Medical CenterHersheyUSA

Personalised recommendations