, Volume 33, Issue 11, pp 1486–1487 | Cite as

Methadone and brain development

  • I. S. Zagon
  • Patricia J. McLaughlin


The effect of maternally administered methadone hydrochloride (5 mg/kg) on brain development of off-spring treated during gestation and/or lactation was studied in 21-day-old rats. Animals treated during gestation or lactation were the most severely affected, with reductions in brain weights (12% and 30%,respectively), and DNA values (50% and 34%, respectively) observed.


Hydrochloride Brain Development Brain Weight 
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Copyright information

© Experientia 1977

Authors and Affiliations

  • I. S. Zagon
    • 1
  • Patricia J. McLaughlin
    • 1
  1. 1.Department of AnatomyThe Milton S. Hershey Medical CenterHersheyUSA

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