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Experientia

, Volume 33, Issue 11, pp 1454–1454 | Cite as

Biochemical studies on peptide alkaloids: Induction of ion selective mitochondrial swelling

  • K. Kawai
  • Y. Nozawa
  • Y. Ogihara
Biologica

Summary

The effect of frangulanine, a cyclopeptide alkaloid isolated fromHovenia dulcis Thunb., on mitochondrial swelling was studied. Frangulanine induced mitochondrial swelling in 0.15 M KCl solution at the concentration of 6.5 μM. The alkaloid showed ion selectivity on the induction of mitochondrial swelling. Upon addition of frangulanine, mitochondria underwent swelling in 0.15 M KCl or RbCl solution but in neither NaCl nor LiCl solution.

Keywords

Peptide Alkaloid LiCl RbCl Biochemical Study 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    M. Takai, Y. Ogihara and S. Shibata, Phytochemistry12, 2985 (1973).Google Scholar
  2. 2.
    M. Takai, Y. Ogihara, Y. Iitaka and S. Shibata, Chem. pharm. Bull.23, 2556 (1975).Google Scholar
  3. 3.
    M. Takai, Y. Ogihara, S. Shibata and Y. Iitaka, Chem. pharm. Bull.24, 2181 (1976).Google Scholar
  4. 4.
    A. Lehninger, Physiol. Rev.42, 467 (1962).PubMedGoogle Scholar
  5. 5.
    A. Azzi and G. F. Azzone, Biochim. biophys. Acta,113, 445 (1966).PubMedGoogle Scholar
  6. 6.
    E. Ogata and H. Rasmussen, Biochemistry5, 57 (1966).PubMedGoogle Scholar
  7. 7.
    J. B. Chappell and A. R. Croft, Biochem. J.95, 393 (1965).PubMedGoogle Scholar
  8. 8.
    N. C. Schneider, J. biol. Chem.176, 259 (1948).Google Scholar
  9. 9.
    O. H. Lowry, N. J. Rosebrough, A. L. Farr and R. J. Randall, J. biol. Chem.193, 265 (1951).PubMedGoogle Scholar

Copyright information

© Experientia 1977

Authors and Affiliations

  • K. Kawai
    • 1
    • 2
  • Y. Nozawa
    • 1
    • 2
  • Y. Ogihara
    • 1
    • 2
  1. 1.Department of BiochemistryGifu University School of MedicineGifuJapan
  2. 2.Department of PharmacognosyPharmaceutical Sciences of Nagoya City UniversityNagoyaJapan

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