, Volume 33, Issue 11, pp 1454–1454 | Cite as

Biochemical studies on peptide alkaloids: Induction of ion selective mitochondrial swelling

  • K. Kawai
  • Y. Nozawa
  • Y. Ogihara


The effect of frangulanine, a cyclopeptide alkaloid isolated fromHovenia dulcis Thunb., on mitochondrial swelling was studied. Frangulanine induced mitochondrial swelling in 0.15 M KCl solution at the concentration of 6.5 μM. The alkaloid showed ion selectivity on the induction of mitochondrial swelling. Upon addition of frangulanine, mitochondria underwent swelling in 0.15 M KCl or RbCl solution but in neither NaCl nor LiCl solution.


Peptide Alkaloid LiCl RbCl Biochemical Study 
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Copyright information

© Experientia 1977

Authors and Affiliations

  • K. Kawai
    • 1
    • 2
  • Y. Nozawa
    • 1
    • 2
  • Y. Ogihara
    • 1
    • 2
  1. 1.Department of BiochemistryGifu University School of MedicineGifuJapan
  2. 2.Department of PharmacognosyPharmaceutical Sciences of Nagoya City UniversityNagoyaJapan

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