Summary
The bromination of α-ergokryptine, a genuine ergot alkaloid of the peptide type, in position 2 of the indol nucleus to 2-bromo-α-ergokryptine is described. Its transformation to the methanesulfonate led to the prolactin inhibitor bromocriptine-methanesulfonate, Parlodel®.
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85. Mitteilung über Mutterkornalkaloide.
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Schneider, H.R., Stadler, P.A., Stütz, P. et al. Synthese und Eigenschaften von Bromocriptin. Experientia 33, 1412–1413 (1977). https://doi.org/10.1007/BF01918774
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DOI: https://doi.org/10.1007/BF01918774