Experientia

, Volume 47, Issue 11–12, pp 1215–1218 | Cite as

Neuronal degeneration in the striatum of the groggy rat: A new mutant with a movement disorder

  • I. K. Takeuchi
  • Y. K. Takeuchi
Research Articles

Abstract

A new mutation displaying abnormal movement was obtained in the progeny of a female Wistar rat which had been given 10 mg/kg methylnitrosourea at an early stage of the gestational period. Genetic studies revealed that the character is inherited by an autosomal single recessive gene, and we designated this mutationgroggy (gene symbolgr). The abnormal movement of the groggy rat was first apparent around postnatal day 15, while the histological studies revealed the appearance of numerous necrotic neurons in the striatum of the groggy rat on postnatal days 60 and 120.

Key words

Neurological mutant movement disorder striatum neuronal degeneration Wistar rat 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Zeman, W., and Innes, J. R. M., Craigie's Neuroanatomy of the Rat. Academic Press, New York 1963.Google Scholar
  2. 2.
    Graybiel, A. M., Ohta, K., and Roffler-Tarlov, S., J. Neurosci.10 (1990) 720.PubMedGoogle Scholar
  3. 3.
    Roffler-Tarlov, S., and Graybiel, A. M., in: The Basal Ganglia II, pp. 443–457. Eds M. B. Carpenter and A. Jayaraman. Plenum Press, New York 1987.Google Scholar
  4. 4.
    Smith, M. W. III, Cooper, T. R., Joh, T. H., and Smith, D. E., Brain Res.510 (1990) 242.CrossRefPubMedGoogle Scholar
  5. 5.
    Roos, R. A. C., in: Handbook of Clinical Neurology, vol. 49, Extrapyramidal Disorders, pp. 315–326. Eds P. J. Vinken, G. W. Bruyn and H. L. Klawans. Elsevier Science Publishers B. V., Amsterdam 1986.Google Scholar
  6. 6.
    Adams, R. D., and Salam-Adams, M., in: Handbook of Clinical Neurology, vol. 49, Extrapyramidal Disorders, pp. 205–212. Eds P. J. Vinken, G. W. Bruyn and H. L. Klawans. Elsevier Science Publishers B. V., Amsterdam 1986.Google Scholar
  7. 7.
    Druschky, K.-F., in: Handbook of Clinical Neurology, vol. 49, Extrapyramidal Disorders, pp. 493–498. Eds P. J. Vinken, G. W. Bruyn and H. L. Klawans. Elsevier Science Publishers B. V., Amsterdam 1986.Google Scholar
  8. 8.
    Jellinger, K., in: Handbook of Clinical Neurology, vol. 49, Extrapyramidal Disorders, pp. 499–518. Eds P. J. Vinken, G. W. Bruyn and H. L. Klawans. Elsevier Science Publishers B. V., Amsterdam 1986.Google Scholar

Copyright information

© Birkhäuser Verlag Basel 1991

Authors and Affiliations

  • I. K. Takeuchi
    • 1
  • Y. K. Takeuchi
    • 2
  1. 1.Department of Embryology, Institute for Developmental ResearchAichi Prefectural ColonyKasugai, AichiJapan
  2. 2.Anatomical LaboratoryGifu College of Medical TechnologySekiJapan

Personalised recommendations