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The rate of action of cyclic ammonium and sulfonium analogues of acetylcholine

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Summary

The rate of action of cyclic acetylcholine analogues in the 4-acetoxypiperidine and 4-acetoxythiacyclohexane series has been determined by using the isolated left guinea-pig atrium. The kinetic data obtained has been correlated with the experimental ED50-value on the muscarinic receptor.

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References

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Authors and Affiliations

  1. Department of Pharmacology, Faculty of Biochemistry and Pharmacy, University of Frankfurt, Robert-Mayer-Strasse 719, D-6000, Frankfurt am Main, Federal Republic of Germany

    G. Lambrecht

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  1. G. Lambrecht
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Additional information

Structure and Conformation Activity Relationships of Cyclic Acetylcholine Analogues.VI.

We thank the German Research Association for supporting this work, and Mrs Ch. Röttger for her valuable assistance in carrying out the investigations.

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Lambrecht, G. The rate of action of cyclic ammonium and sulfonium analogues of acetylcholine. Experientia 35, 75–76 (1979). https://doi.org/10.1007/BF01917886

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  • DOI: https://doi.org/10.1007/BF01917886

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