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The effect of bisamidines of 2,6-diaminoanthraquinone onEntamoeba histolytica infections in rats and hamsters

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Summary

Bisamidines of 2,6-diaminoanthraquinone have demonstrated potent activity against cecal and hepaticEntamoeba histolytica infections in rats and hamsters, respectively. A number of these compounds compared favorably, in overall drug efficacy, with metronidazole and other standard agents.

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References

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Authors and Affiliations

  1. Infectious Disease Research Section, Medical Research Division, American Cyanamid Company, 10965, Pearl River, New York, USA

    E. J. Burden, S. G. Carvajal, P. F. Fabio, T. L. Fields, Yang-I Lin, K. C. Murdock & S. A. Lang Jr

Authors
  1. E. J. Burden
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  2. S. G. Carvajal
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  3. P. F. Fabio
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  4. T. L. Fields
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  5. Yang-I Lin
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  6. K. C. Murdock
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  7. S. A. Lang Jr
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Additional information

Acknowledgements. The authors wish to thank Dr B. Jackson and co-workers for the results in the Dominant-Lethal test and N.A. Kuck for the results in the Ames test.

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Burden, E.J., Carvajal, S.G., Fabio, P.F. et al. The effect of bisamidines of 2,6-diaminoanthraquinone onEntamoeba histolytica infections in rats and hamsters. Experientia 35, 33–35 (1979). https://doi.org/10.1007/BF01917859

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  • DOI: https://doi.org/10.1007/BF01917859

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