Advertisement

Experientia

, Volume 34, Issue 8, pp 1047–1049 | Cite as

Interaction of chlorpromazine with organic solvents and fatty acids as studied by UV-spectrophotometry

  • M. H. Bickel
  • J. Römer
Specialia

Summary

The magnitude of the UV-spectral change of chlorpromazine increases in the presence of increasing concentrations of alcohols or fatty acids and with increasing chain length. A maximum is reached with 14.0- or 16.0-fatty acids. The difference spectrum is still larger with unsaturated fatty acids, a maximum effect being obtained with one cis-double bond. The spectral change is abolished by chaotropic and enhanced by antichaotropic agents.

Keywords

Alcohol Organic Solvent Chain Length Unsaturated Fatty Acid Chlorpromazine 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 2.
    M.H. Bickel and J.W. Steele, Chem. biol. Interact.8, 151 (1974).PubMedGoogle Scholar
  2. 3.
    C. di Francesco and M.H. Bickel, Chem. biol. Interact.16, 335 (1977).PubMedGoogle Scholar
  3. 4.
    M.H. Bickel and H.G. Weder, Psychopharmac. Commun.2, 231 (1976).Google Scholar
  4. 5.
    P.C. Huang and S. Gabay, Biochem. Pharmac.23, 957 (1974).Google Scholar
  5. 6.
    D. Attwood, A.T. Florence and J.M.N. Gillan, J. pharm. Sci.63, 988 (1974).PubMedGoogle Scholar
  6. 7.
    P. Mukerjee, J. pharm. Sci.63, 972 (1974).PubMedGoogle Scholar
  7. 8.
    C. Tanford, in: The Hydrophobic Effect: Formation of Micelles and Biological Membranes. J. Wiley & Sons, New York 1973.Google Scholar
  8. 9.
    P. Mukerjee and K.J. Mysels, in: Critical Micelle Concentrations of Aqueous Surfactant Systems, U.S. Department of Commerce, Washington 1971.Google Scholar
  9. 10.
    J. Kirschbaum, J. pharm. Sci.63, 981 (1974).PubMedGoogle Scholar

Copyright information

© Birkhäuser Verlag 1978

Authors and Affiliations

  • M. H. Bickel
    • 1
  • J. Römer
    • 1
  1. 1.Department of PharmacologyUniversity of BerneBerne(Switzerland)

Personalised recommendations