Interaction of chlorpromazine with organic solvents and fatty acids as studied by UV-spectrophotometry
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The magnitude of the UV-spectral change of chlorpromazine increases in the presence of increasing concentrations of alcohols or fatty acids and with increasing chain length. A maximum is reached with 14.0- or 16.0-fatty acids. The difference spectrum is still larger with unsaturated fatty acids, a maximum effect being obtained with one cis-double bond. The spectral change is abolished by chaotropic and enhanced by antichaotropic agents.
KeywordsAlcohol Organic Solvent Chain Length Unsaturated Fatty Acid Chlorpromazine
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