, Volume 34, Issue 8, pp 1047–1049 | Cite as

Interaction of chlorpromazine with organic solvents and fatty acids as studied by UV-spectrophotometry

  • M. H. Bickel
  • J. Römer


The magnitude of the UV-spectral change of chlorpromazine increases in the presence of increasing concentrations of alcohols or fatty acids and with increasing chain length. A maximum is reached with 14.0- or 16.0-fatty acids. The difference spectrum is still larger with unsaturated fatty acids, a maximum effect being obtained with one cis-double bond. The spectral change is abolished by chaotropic and enhanced by antichaotropic agents.


Alcohol Organic Solvent Chain Length Unsaturated Fatty Acid Chlorpromazine 
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Copyright information

© Birkhäuser Verlag 1978

Authors and Affiliations

  • M. H. Bickel
    • 1
  • J. Römer
    • 1
  1. 1.Department of PharmacologyUniversity of BerneBerne(Switzerland)

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