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Increased blood pressure in the SHR is not related to a deficit in renomedullary PGE2

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Summary

Synthesis of prostaglandin E2 by renal medulla from SHR and WKY rats was compared during early postnatal development. Although arterial blood pressure was significantly higher in SHR as early as 6 weeks of age, no difference in renal medullary prostaglandin synthesis was observed.

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Authors and Affiliations

  1. Department of Pharmacology, Michigan State University, 48824, East Lansing, Michigan, USA

    V. G. Stygles, D. A. Reinke, D. E. Rickert & J. B. Hook

Authors
  1. V. G. Stygles
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  2. D. A. Reinke
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  3. D. E. Rickert
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  4. J. B. Hook
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Additional information

Supported in part by a grant from the michigan Heart Association and NIH grant AM-10913.

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Stygles, V.G., Reinke, D.A., Rickert, D.E. et al. Increased blood pressure in the SHR is not related to a deficit in renomedullary PGE2. Experientia 34, 1025–1026 (1978). https://doi.org/10.1007/BF01915324

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  • DOI: https://doi.org/10.1007/BF01915324

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