Summary
Recent evidence has revived the idea that translocation of macromolecules between nucleus and cytoplasm may be regulated via expansion and contraction of the entire diameter of the nuclear pore complex. The present investigation does not support this hypothesis.
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References
J.H.M. Willison and R. Rajaraman, Proc. Fedn biol. Soc.19, 244a (1976); J. Cell Biol.70, 226a (1976); J. Microsc.109, 183 (1977).
W.W. Franke, Int. Rev. Cytol., suppl.4, 71 (1974).
W.W. Franke, Phil. Trans. R. Soc. Lond. B268, 67 (1974).
W.W. Franke and U. Scheer, in: The Cell Nucleus, vol., p. 219. Ed. H. Busch. Academic Press, New York 1974.
W.W. Franke and U. Scheer, Symp. Soc. exp. Biol.28, 249 (1974).
F. Wunderlich, R. Berezney and H. Kleinig, in: Biological Membranes, p. 241. Ed. D. Chapman and D.F.H. Wallach. Academic Press, New York 1976.
H.G. Callan, J.R. Randall and S.G. Tomlin, Nature163, 280 (1949).
D. Branton and H. Moor, J. Ultrastruct. Res.11, 401 (1964).
E.J. DuPraw, in: DNA and Chromosomes, p. 205. Holt, Reinhart and Winston, New York 1970.
J. Kartenbeck, H. Zentgraf, U. Scheer and W.W. Franke, Adv. Anat. Embryol. Cell Biol.45, 1 (1971).
S. Bullivant, in: Advanced Techniques in Biological Electron Microscopy, p. 67. Ed. J.K. Koehler. Springer-Verlag, Heidelberg 1973.
E.G. Jordan, N.J. Severs and D.H. Williamson, Exp. Cell Res.104, 446 (1977).
N.J. Severs, Cytobios.18, 51 (1977).
A. Monneron, G. Blobel and G.E. Palade, J. Cell Biol.55, 104 (1972).
N.J. Severs and E.G. Jordan, J. Ultrastruct. Res.52, 85 (1975).
P.L. Paine, L.C. Moore and S. Horowitz, Nature254, 109 (1975).
T.P. Liu, Tissue Cell4, 493 (1972).
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Acknowledgments. We are indebted to Dr J.H.M. Willison for discussion of his and Dr Rajaraman's results before their publication. We also wish to thank Dr C. Thurston, Dr D.H. Williamson and Dr K. Lambert for providing some of the specimens used in this investigation. N.J. Severs acknowledges the support of the Science Research Council and the Cancer Research Campaign.
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Severs, N.J., Jordan, E.G. Nuclear pores. can they expand and contract to regulate nucleocytoplasmic exchange?. Experientia 34, 1007–1011 (1978). https://doi.org/10.1007/BF01915314
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DOI: https://doi.org/10.1007/BF01915314