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Etude thermoanalytique de substances medicamenteuses

II-Détermination de la pureté de l'aminophénazone (I) par analyse thermique

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Abstract

The authors have determined the degree of purity on different samples of aminophenazone (I) containing very small quantities of phenazone and amino-4-phenazone. The advantages of differential scanning calorimetry and the of transparency recording in the change from the solid to the liquid state during the fusion is shown.

Résumé

Les auteurs ont déterminé le taux de pureté de différents échantillons d'aminophénazone (I) dont certains renferment de très faibles quantités de phénazone et d'amino-4 phénazone. L'intérÊt de l'analyse calorimétrique différentielle et de la mesure de la transparence résultant du changement de phase solide-liquide au cours de la fusion a été souligné.

Zusammenfassung

Die Autoren bestimmten den Reinheitsgrad verschiedener Aminophenazonproben, welche sehr geringe Mengen an Phenazon und Amino-4-Phenazon enthielten. Die Vorteile der Differential-Abtastkalorimetrie und der Messung der bei dem übergang vom festen in den flüssigen Zustand auftretenden Transparenz im Laufe des Schmelzvorganges werden betont.

РЕжУМЕ

АВтОРы ОпРЕДЕлИлИ ст ЕпЕНь ЧИстОты РАжлИЧ Ных ОБРАжцОВ АМИНОФЕНАж ОНА, сОДЕРжАЩИх ОЧЕНь МАлыЕ кОлИЧЕст ВА ФЕНАжОНА И 4-АМИНОФЕ НАжОНА. пОкАжАНО пРЕИМУЩЕст ВО ДИФФЕРЕНцИАльНОИ ск АНИРУУЩЕИ кАлОРИМЕт РИИ И РЕгИстРИРУЕМОИ пРОж РАЧНОстИ пРИ пЕРЕхОД Е Иж тВЕРДОгО сОстОьНИ ь В жИДкОЕ ВО ВРЕМь плА ВлЕНИь.

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Authors and Affiliations

  1. Laboratoire de Chimie Générale et Minérale, U.E.R. des Sciences Pharmaceutiques, 34000, Montpellier, France

    J. Masse & A. Chauvet

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  1. J. Masse
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  2. A. Chauvet
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Masse, J., Chauvet, A. Etude thermoanalytique de substances medicamenteuses. Journal of Thermal Analysis 14, 313–324 (1978). https://doi.org/10.1007/BF01915169

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  • DOI: https://doi.org/10.1007/BF01915169

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