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Human spleen inhibitor of leukaemic cell growth

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En este trabajo se describe la purificación de un inhibidor de la síntesis de ARN que afecta secundariamente la síntesis de ADN, y actividad mitótica. El factor ha sido aislado de ocho bazos humanos, comprendiendo dos de enfermos con leucemia mielocítica crónica (LMC) sanas, en los cuales se efectuó la esplenectomía por ruptura traumática del bazo El inhibidor esplénico posee fuerte citotoxicidad sobre células en cultivo provenientes de enfermos con LMC. Estas células tienen el cromosoma de Philadelphia. El inhibidor esplénico tiene un peso molecular de alrededor de 1,000 y es probablaemente un péptido o glicopéptido.

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Authors and Affiliations

  1. Memorial Research Center and Hospital 1924, The University of Tennessee, Alcoa Highway, 37920, Knoxville, Tennessee, USA

    B. B. Lozzio, Carmen B. Lozzio & Elena G. Bamberger

Authors
  1. B. B. Lozzio
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  2. Carmen B. Lozzio
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  3. Elena G. Bamberger
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Lozzio, B.B., Lozzio, C.B. & Bamberger, E.G. Human spleen inhibitor of leukaemic cell growth. Experientia 29, 87–89 (1973). https://doi.org/10.1007/BF01913270

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