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Shortened duration of drug-induced behavioral excitation in rats with septal lesions

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En las ratas, la reacción elevada de la respuesta evasiva, después de darles iproniazida y tetrabenazina aparentemente está relacionada con el suelto acrecentado de acetylcholina en al parte frontal del cerebro. Cuando las ratas con lesiones septales recibieron estas dos drogas, sus periódos resultantes de excitacion de conducta eran significantamente mas cortos que los de los controles. Como las lesiones septales producen disminución en los niveles de la acetylcholina en el cerebro, estos datos implicaron más el sistema cholinergica en la excitación producida por la iproniziada-tetrabenazina.

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References

  1. M. H. Aprison, T. Kariya, J. N. Hingtgen andM. Toru, J. Neurochem.15, 1131 (1968).

    Article  CAS  PubMed  Google Scholar 

  2. M. H. Aprison andJ. N. Hingtgen, inDrugs and Cholinergic Mechanisms in the CNS (E. Heilbronn andA. Winter, Research Institute of National Defence, Stockholm 1970), p. 543.

    Google Scholar 

  3. J. N. Hingtgen andM. H. Aprison, Neuropharmacology9, 419 (1970).

    Article  CAS  PubMed  Google Scholar 

  4. M. Toru, J. N. Hingtgen andM. H. Aprison, Life Sci.5, 181 (1966).

    Article  CAS  PubMed  Google Scholar 

  5. M. H. Aprison andJ. N. Hingtgen, Biol. Psychiat.1, 87 (1969).

    CAS  PubMed  Google Scholar 

  6. G. Pepeu, A. Mulas, A. Ruffi andP. Sotgiu, Life Sci.10, 181 (1971).

    Article  CAS  Google Scholar 

  7. J. P. Sorensen andJ. A. Harvey, Physiol. Beh.6, 723 (1971).

    Article  Google Scholar 

  8. L. J. Pellegrino andA. J. Cushman,A Stereotaxic Atlas of the Rat Brain; Appleton-Century-Crofts, New York (1967).

    Google Scholar 

  9. M. H. Aprison, Rec. Advances Biol. Psychiat.4, 133 (1962).

    Article  Google Scholar 

  10. Supported in part by grants No. MH-03225-13 and No. MH-10695-06 from the National Institute of Mental Health, USPHS. We thank Hoffmann-LaRoche, Inc. for providing the tetrabenazine (Nitoman) and iproniazid (Marsilid) used in these studies.

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Authors and Affiliations

  1. Section of Neurobiology, The Institute of Psychiatric Research, Indiana University School of Medicine, 1100 West Michigan Street, 46202, Indianapolis, Indiana, USA

    J. N. Hingtgen, M. H. Aprison, W. C. Black & J. C. Sloan

  2. Department of Psychiatry and Biochemistry, Indiana University School of Medicine, 1100 West Michigan Street, 46202, Indianapolis, Indiana, USA

    J. N. Hingtgen, M. H. Aprison, W. C. Black & J. C. Sloan

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  1. J. N. Hingtgen
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  2. M. H. Aprison
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  3. W. C. Black
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  4. J. C. Sloan
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Hingtgen, J.N., Aprison, M.H., Black, W.C. et al. Shortened duration of drug-induced behavioral excitation in rats with septal lesions. Experientia 29, 74–75 (1973). https://doi.org/10.1007/BF01913261

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