Journal of thermal analysis

, Volume 37, Issue 8, pp 1869–1875 | Cite as

Polymorphism of progesterone

Influence of the carrier and of the solid dispersion manufacturing processes. A calorimetric and radiocrystallographic study
  • R. Duclos
  • J. M. Saiter
  • J. Grenet
  • A. M. Orecchioni


Solid dispersions are used in pharmaceutical technology in order to improve solubility and/or dissolution kinetics of poorly water soluble drugs [1, 2, 3]. A preliminary study concerning progesterone structure after melting revealed the existence of a drug polymorphism after cooling, and gave the opportunity to specify the manufacturing conditions in order to obtain the stable form of this hormone [4]. In this work, two different types of progesterone solid dispersion have been compared. The first one is obtained by a slow cooling rate of the drug in the presence of polyoxyethylene glycol 6000 and the second one after quenching in the presence of saccharose distearate.

DSC and radiocrystallographic studies of the solid dispersions served to specify the nature of the compounds obtained and to characterize the physical structure of the hormone in the solidified melts.


Cool Rate Progesterone Solid Dispersion Slow Cool Physical Structure 
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Dispersionen werden in der pharmazeutischen Technologie angewendet zur Erhöhung der Bioverfügbarkeit schlecht wasserlöslicher Wirksubstanzen. In einer Voruntersuchung konnte durch Schmelzen von Progesteron gezeigt werden, dass polymorphe Formen existieren. Unterschiedliche ProgesteronprÄparate wurden durch Mischungen einerseits mit Polyethylenglykol 6000 und andererseits mit Saccharosedistearat hergestellt, wobei verschiedene Erstarrungsprozesse angewendet wurden.

Die Methoden der DSC und der Röntgendiffraktion wurden zur Charakterisierung der erhaltenen Festkörper eingesetzt.


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Copyright information

© Wiley Heyden Ltd., Chichester and Akadémiai Kiadó, Budapest 1991

Authors and Affiliations

  • R. Duclos
    • 1
  • J. M. Saiter
    • 2
  • J. Grenet
    • 2
  • A. M. Orecchioni
    • 1
  1. 1.Laboratoire de Pharmacie GaleniqueUFR de Medicine-Pharmacie de RouenSaint Etienne Rouvray CedexFrance
  2. 2.Laboratoire L. E. C. A. P.UFR des Sciences et Techniques de RouenMont-Saint-Aignan CedexFrance

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