Abstract
A theoretical description of the proton dissociation process of weak polyacids is given. Incorporation of conformational variability in the free energy of a polyelectrolyte system provides quantitative fitting of experimental data. In addition, it extends the validity of the theory to cases in which a cooperative order-disorder transition takes place. Biopolymers considered are: poly(L-aspartic acid), poly(L-glutamic acid), samples of poly(uronic acid) and some carboxylic derivatives of a gelling bacterial polysaccharide.
Zusammenfassung
Eine theoretische Betrachtung der Protonendissoziation schwacher PolysÄuren wird dargelegt. Die Berücksichtigung konformativer Änderungen auf die Grösse der freien Energie eines polyelektrolytischen Sytems ermöglicht eine theoretische Berechnung der Titrationskurven von Poly-L-AsparaginsÄure als auch der Konformationsumwandlungen einiger Biopolymeren wie Poly-L-GlutaminsÄure und carboxylierten Derivative von Polisacchariden.
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The author wishes to thank the many colleagues and coworkers, who contribute to the results presented for the STK Award Lecture. Research described has been carried out with financial support from the CNR, the University of Trieste, and in the framework of the Bilateral Agreements between CNR-CONICET, and the University of Trieste and the University of San Luis.
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Cesàro, A. On the thermodynamics of proton dissociation in weak biological polyacids. Journal of Thermal Analysis 37, 1851–1868 (1991). https://doi.org/10.1007/BF01912216
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DOI: https://doi.org/10.1007/BF01912216