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Vasoconstrictor agents correlatively alter diameter and tension development in isolated pig coronary arteries

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Summary

Outer diameter of the isolated pig coronary artery was measured under isotonic conditions using a sonomicrometer, and tension development of a ring preparation was assessed isometrically by a strain gauge transducer. Potassium chloride (KCl), acetylcholine (ACh) and 5-hydroxytryptamine dose-dependently reduced the coronary outer diameter. There was a direct linear relation between the reduction of diameter and tension development by these agents (r=0.91, n=15, p<0.001). KCl was one of the most potent vasoconstrictors tested and reduced the outer diameter by 35±1% (n=15, mean ± SEM) at 120 mM. ACh produced a transient increase in isometric tension and the reduction of the coronary diameter by ACh was smaller than that seen with KCl, even with a dose which produced the similar peak level of isometric tension by KCl and ACh. It is concluded that changes in the coronary diameter do closely correlate with those in tension development, however, the reduction of coronary diameter after exposure to vasoconstrictive agents is less in phasic than tonic contraction. The latter evidence suggests the importance of both the sterngth and duration of active vasoconstriction in eliciting coronary spasm.

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References

  1. Cox RH (1976) Mechanics of canine iliac artery smooth muscle in vitro. Am J Physiol 230:462–470

    PubMed  Google Scholar 

  2. Cox RH (1983) Comparison of arterial wall mechanics using ring and cylindrical segments. Am J Physiol 244:H298-H303

    PubMed  Google Scholar 

  3. Dobrin PB, Rovick AA (1969) Influence of vascular smooth muscle on contractile mechanics and elasticity of arteries. Am J Physiol 217:1644–1652

    PubMed  Google Scholar 

  4. Franklin D, Kemper WS, Patrick T, McKown D (1973) Technique for continuous measurement of regional myocardial segment dimensions in chronic animal preparations (Abstract). Federation Proc 32:343

    Google Scholar 

  5. Gould KL, Lipscomb K, Hamilton GW (1974) Physiologic basis for assessing critical coronary stenosis. Am J Cardiol 33:87–94

    PubMed  Google Scholar 

  6. Gow BS, Hadfield CD (1979) The elasticity of canine and human coronary arteries with reference to postmortem changes. Circ Res 45:588–594

    PubMed  Google Scholar 

  7. Holtz J, Giesler M, Bassenge E (1983) Two dilatory mechanisms of anti-anginal drugs on epicardial coronary arteries in vivo: Indirect, flow-dependent, endothelium-mediated dilation and direct smooth muscle relaxation. Z Kardiol 72 suppl 3:98–106

    PubMed  Google Scholar 

  8. Ito Y, Kitamura K, Kuriyama H (1979) Effects of acetylcholine and catecholamines on the smooth muscle cell of the porcine coronary artery. J Physiol 294:595–611

    PubMed  Google Scholar 

  9. Kawachi Y, Tomoike H, Maruoka Y, Kikuchi Y, Araki H, Ishii Y, Tanaka K, Nakamura M (1984) Selective hypercontraction to ergonovine of the dog coronary artery under conditions of induced atherosclerosis. Circulation 69:441–450

    PubMed  Google Scholar 

  10. MacAlpin RN (1980) Relation of coronary arterial spasm to sites of organic stenosis. Am J Cardiol 46:143–153

    PubMed  Google Scholar 

  11. MacAlpin RN (1980) Contribution of dynamic vascular wall thickening to luminal narrowing during coronary arterial constriction. Circulation 60:296–301

    Google Scholar 

  12. Oliva PB, Potts DE, Pluss PG (1973) Coronary arterial spasm in Prinzmetal's angina. Documentation by coronary arteriography. N Engl J Med 288:745–751

    PubMed  Google Scholar 

  13. Pérez JE, Saffitz JE, Gutiérrez FA, Henry PD (1983) Coronary artery spasm in intact dogs induced by potassium and serotonin. Circ Res 52:423–431

    PubMed  Google Scholar 

  14. Porquet ME, Pourrias B, Santamaria P (1982) Effect of 5-hydroxytriptamine on canine isolated coronary arteries. Br J Pharmacol 75:305–310

    PubMed  Google Scholar 

  15. Shimokawa H, Tomoike H, Nabeyama S, Yamamoto H, Araki H, Nakamura M, Ishi Y, Tanaka K (1983) Coronary artery spasm induced in atherosclerotic miniature swine. Science 221: 560–562

    PubMed  Google Scholar 

  16. Toda N (1981) Responses of isolated monkey coronary arteries to catecholamines and to transmural electrical stimulation. Circ Res 49:1228–1236

    PubMed  Google Scholar 

  17. Tomoike H, Ootsubo H, Sakai K, Kikuchi Y, Nakamura M (1981) Continuous measurement of coronary artery diameter in situ. Am J Physiol 240:H73-H79

    PubMed  Google Scholar 

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Author notes

  1. H. Tomoike M.D.

    Present address: Research Institute of Angiocardiology and Cardiovascular Clinic, Kyushu University, Faculty of Medicine, 3-1-1 Maidashi, Higashi-ku, Fukuoka, (Japan)

Authors and Affiliations

  1. Research Institute of Angiocardiology and Cardiovascular Clinic, Kyushu University, Faculty of Medicine, 3-1-1 Maidashi, Higashi-ku, Fukuoka, (Japan)

    Y. Nagata, H. Araki & M. Nakamura

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  1. Y. Nagata
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  2. H. Araki
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  3. H. Tomoike M.D.
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  4. M. Nakamura
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Nagata, Y., Araki, H., Tomoike, H. et al. Vasoconstrictor agents correlatively alter diameter and tension development in isolated pig coronary arteries. Basic Res Cardiol 80, 210–217 (1985). https://doi.org/10.1007/BF01910469

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  • DOI: https://doi.org/10.1007/BF01910469

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