Summary
Daily heparin injections (300 mg s.c.) during four weeks of hypoxic exposure resulted in a smaller rise in pulmonary artery pressure as compared with otherwise nontreated rats exposed to the same regimen of hypoxia.
Heparin treatment did not significantly affect the systemic arterial pressure of the hypoxic rats.
In spite of the different pressure load of the right ventricle after hypoxia in treated and control rats, there was no difference in parameters indicative of the degree of right ventricular hypertrophy between these two groups of hypoxic rats. This finding suggests that the difference in pressure load between the two groups of hypoxic rats occurred late in the course of hypoxic exposure.
Similar content being viewed by others
References
Guyton J, Rosenberg R, Clowes A, Karnovsky MJ (1980) Inhibition of rat arterial smooth muscle cell proliferation by heparin. Circ Res 46:628–633
Hatcher JD, Sunahara FA, Edholm OG, Woolmer JM (1954) The circulatory adjustment to posthemorrhagic anemia in dogs. Circ Res 2:499–505
Kentera D, Sušić D, Zdravković M, Kanjuh V, Tucaković G (1978) Chronic pulmonary hypertension—animal model of human disease. Comp Pathol Bull 10:1–4
Kentera D, Sušić D, Zdravković M (1978) Blood viscosity and experimental chronic pulmonary hypertension. Jugoslav Physiol Pharmacol Acta 14:118–120
Mandal AK, Oleinick SR, James TM, Wise W, Zong H, Nordquist JA, Bell RD, Yunice AA, Parker D (1978) Glomerular thrombosis in spontaneously hypertensive rat. III. Effect of heparin. Microvasc Res 16:373–379
McDonald KM (1974) Effect of hematocrit and colloid-induced changes in blood viscosity on renal hemodynamics and renin release in the dog. Circ Res 34:112–122
Richardson TQ, Guyton AC (1959) Effects of polycythemia and anemia on cardiac output and other circulatory factors. Am J Physiol 197:1167–1170
Sušić D, Haxhiu M, Kentera D (1981) Decreased pulmonary pressor response to acute hypoxia in chronically hypoxic rats. Respiration 41:166–173
Sušić D, Mandal AK, Kentera D (1982) Heparin lowers the blood pressure in hypertensive rats. Hypertension 4:681–685
Sušić D, Mandal AK, Kentera D (1984) Hemodynamic effects of chronic alteration in hematocrit in SH rats. Hypertension 6:262–266
Whittaker SRF, Winton FR (1933) The apparent viscosity of blood flowing in the isolated hind limb of the dog and its variation with corpuscular concentration. J Physiol 78:339–345
Wilson SK, Solez K, Biotnott JK, Heptinstall RH (1981) The effect of heparin treatment on hypertension and vascular lesions in stroke-prone SH rats. Am J Pathol 102:62–68
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Kentera, D., Sušić, D. & Zdravković, M. Hypotensive effect of heparin on experimental chronic pulmonary hypertension in rats. Basic Res Cardiol 80, 142–146 (1985). https://doi.org/10.1007/BF01910461
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF01910461