Annals of Hematology

, Volume 71, Issue 4, pp 161–168 | Cite as

Plasma levels of IL-1, TNF alpha, IL-6, IL-8, G-CSF, and IL1-RA during febrile neutropenia: Results of a prospective study in patients undergoing chemotherapy for acute myelogenous leukemia

  • H. Schönbohn
  • M. Schuler
  • K. Kolbe
  • C. Peschel
  • C. Huber
  • W. Bemb
  • W. E. Aulitzky
Original Article


Plasma levels of IL-1, IL-6, IL-8, IL1-RA, TNF alpha, and G-CSF were prospectively studied during 23 chemotherapy cycles of 20 patients suffering from acute myelogenous leukemia. Increased plasma levels of IL-6, IL-8, and G-CSF were observed in patients with febrile neutropenia and/or major infection. Plasma levels of IL-6, IL-1, TNF alpha and IL-1-RA measured 1 day before and 1 day after the onset of febrile episodes did not accurately predict the development of major infection. In contrast, IL-8 plasma levels were significantly higher in those patients who subsequently developed major infection. The question whether IL-8 plasma levels identify high risk or low risk patients with sufficient specificity and sensitivity has to be answered in large scale clinical trials.

Key words

Plasma levels Interleukin Neutropenia 


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Copyright information

© Springer-Verlag 1995

Authors and Affiliations

  • H. Schönbohn
    • 1
  • M. Schuler
    • 1
  • K. Kolbe
    • 1
  • C. Peschel
    • 1
  • C. Huber
    • 1
  • W. Bemb
    • 1
  • W. E. Aulitzky
    • 1
  1. 1.Department of Microbiology, Division of Hematology, Third Department of Internal MedicineUniversity Hospital MainzMainzGermany

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