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The influence of calcium and β-sympathomimetics on force-frequency relationship and resting potentiation in guinea pig papillary muscle

Der Einfluß von Calcium und β-Sympathomimetika auf die Kraft-Frequenz-Beziehung und Ruhepotenzierung des Papillarmuskels des Meerschweinchens

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Summary

The influence of various calcium concentrations and of the β-sympathomimeticum orciprenaline (Alupent®) on the force-frequency relationship and on the resting potentiation of isolated isometrically contracting papillary muscles of the guinea pig heart was studied. Elevation of Ca concentration and/or addition of orciprenaline augment the amplitudes of contractions elicited by rhythmical stimulation, but they diminish the amplitudes of test contractions elicited after a test interval of 1–2 s. It is suggested that calcium and orciprenaline strenghten the calcium loss from the sarcoplasmic reticulum out of the cell during a prolonged interval.

Zusammenfassung

Der Einfluß der Calciumionenkonzentration und des Zusatzes des β-Sympathomimetikums Orciprenalin (Alupent®) auf die Kraft-Frequenz-Beziehung und die Ruhepotenzierung am isolierten, sich isometrisch kontrahierenden Papillarmuskel des Meerschweinchenherzens wurde geprüft. Die Erhöhung der Calciumkonzentration und/oder Zusatz von Orciprenalin zur Badlösung erhöhen die Kontraktionsamplituden bei rhythmischer Reizung, sie vermindern aber die Amplituden der Testkontraktionen nach 1–2 s langen Testintervallen. Die Befunde machen es wahrscheinlich, daß durch hohe Calciumaußenkonzentrationen und durch Orciprenalin der Calciumausstrom aus dem sarcoplasmatischen Retikulum in den Extrazellulärraum während eines verlängerten Intervalls verstärkt wird.

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Author notes

  1. E. Rumberger

    Present address: Physiological Institute and II. Medical Clinic of the University Hamburg, Martinistraße 52, 2000, Hamburg 20

Authors and Affiliations

  1. Physiological Institute and II. Medical Clinic of the University Hamburg, Martinistraße 52, 2000, Hamburg 20

    M. Hanafy & J. Kitzing

Authors
  1. M. Hanafy
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  2. J. Kitzing
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  3. E. Rumberger
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Additional information

Dedicated to Prof. Dr.H. Reichel for his 65th birthday.

With 5 figures and 1 table

Supported by a grant of “Deutscher Akademischer Austauschdienst”.

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Hanafy, M., Kitzing, J. & Rumberger, E. The influence of calcium and β-sympathomimetics on force-frequency relationship and resting potentiation in guinea pig papillary muscle. Basic Res Cardiol 71, 469–481 (1976). https://doi.org/10.1007/BF01909763

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  • DOI: https://doi.org/10.1007/BF01909763

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