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The Journal of Membrane Biology

, Volume 40, Issue 1, pp 39–66 | Cite as

Kinetic properties of electrostatic pores with orientable dipoles, for Na+ and K+ transport through biological membranes

  • D. Van Lamsweerde-Gallez
  • A. Meessen
Article

Summary

The model, used previously to account for the transport of K+ ions through squid axon membranes under steady-state conditions, is extended to the description of the kinetic behavior of Na+ and K+ currents, for sudden variations of the applied potential. Theoretical curves are obtained by numerical integration of the electrodiffusion equation for ions within pores, with variable boundary conditions resulting from a progressive reorientation of dipoles at the pore surfaces. The pores are supposed to be selective and the dipole parameters are allowed to be different for Na+ and K+ pores.

The K+ current varies with time, in agreement with the K+ dipole parameters deduced from the steady-state results of Gilbert and Ehrenstein (1969). The dipole parameters for the Na+ current are deduced from the steady-state results of Armstrong, Bezanilla & Rojas (1973), where the inactivation phase of the Na+ current is suppressed by introducing pronase in the inside solution. The dipole reorientation is relevant to explain the sigmoid shape of the activation phase of the Na+ current, while the inactivation phase seems to resort to another physical mechanism. The predictions based on this model agree with the experimental results for the steady-statenegative resistance and thegating current, associated both with a reorientation of surface dipoles, as well as the activation phase of the Na+ current using a consistent set of parameters for all these comparisons.

Keywords

Activation Phase Variable Boundary Kinetic Behavior Inside Solution Theoretical Curf 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag New York Inc 1987

Authors and Affiliations

  • D. Van Lamsweerde-Gallez
    • 1
  • A. Meessen
    • 1
  1. 1.Institut de PhysiqueUniversité Catholique de LouvainLouvain-la-NeuveBelgium

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