Skip to main content
SpringerLink
Log in

Etude des melanges binaires khelline-cafeine et khelline-sulfapyridine

  • Published:
Journal of thermal analysis Aims and scope Submit manuscript

Abstract

After studying the thermal behaviours of the drugs, the authors established the state diagrams of the binary systems khellin(I)-caffeine(I) and khellin(I)-sulfapyridine(I) by thermomicroscopy, differential scanning calorimetry and differential thermal analysis.

Eutectic, peritectic and molecular compound khellin(I)-caffeine(I) compositions were determined for a physico-chemical study, particularly of solubility, in relation with bioavailability.

Résumé

Après avoir étudié le comportement thermique des principes actifs les auteurs ont établi les diagrammes de phase des mélanges binaires khelline(I)-caféine(I) et khelline(I)-sulfapyridine(I) par thermomicroscopie, analyse thermique et calorimétrique différentielles. Les compositions des eutectiques, du péritectique et du composé défini khelline(I)-caféine(I) ont été déterminées en vue d'une étude physico-chimique, plus particulièrement de solubilité en relation avec la biodisponibilité.

Zusammenfassung

Nach der Untersuchung des thermischen Verhaltens von Wirkstoffen (Drogen) bestimmten die Autoren die Phasendiagramme der BinÄrsysteme Khellin(I)-Koffein(I) und Khellin(I)-Sulfapyridin(I) durch Thermomikroskopie, Thermoanalyse und Differentialkalorimetrie. Die Zusammensetzung der Eutektika, des Peritektikums und der Molekularverbindung Khellin(I)-Koffein(I) wurden zu physikalisch-chemischen Untersuchungen, insbesondere der Löslichkeit im Zusammenhang mit der BiodisponibilitÄt, bestimmt.

РЕжУМЕ

пРИ ИжУЧЕНИИ тЕРМИЧЕ скОгО пОВЕДЕНИь НАРкОтИкОВ с пОМОЩьУ тЕРМОМИкРОскОпИИ, ДИФФЕРЕНцИАльНОИ ск АНИРУУЩЕИ кАлОРИМЕт РИИ И ДИФФЕРЕНцИАльНОгО т ЕРМИЧЕскОгО АНАлИжА, АВтОРы ОпРЕД ЕлИлИ ДИАгРАММы сОст ОьНИь БИНАРНых сИстЕМ хЕлл ИН(II) —кОФЕИН(II) И хЕллИН(II)-сУльФАпИРИД ИН(II). сОстАВ ЁВтЕктИк, пЕРИтЕктИкИ И МОлЕкУ льРНОгО сОЕДИНЕНИь хЕллИН-кО ФЕИН ОпРЕДЕлЕН с цЕль У ДАльНЕИшЕгО ФИжИкО-х ИМИЧЕскОгО ИсслЕДОВАНИь И В ОсОБ ЕННОстИ РАстВОРИМОс тИ Их, В сВьжИ с БИООБЕжВРЕжИВАНИЕ М.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Bibliographie

  1. L. Kofler etA. Kofler, Thermomikromethoden, Wagner, Innsbruck, 1954.

    Google Scholar 

  2. M.Kuhnert-Brandstatter, Thermomicroscopy in the Analysis of Pharmaceuticals, Pergamon Press, 1971.

  3. J. K. Guillory, S. C. Hang etJ. L. Lach, J. Pharm. Sci., 58 (1969) 301.

    PubMed  Google Scholar 

  4. K. Sekiguchi, I. Imuro, I. Horikoshi, T. Tsukada, T. Okamoto etI. Yotsuyanagi, Chem. Pharm. Bull., Tokyo 17 (1969) 191.

    Google Scholar 

  5. A. M. Saleh, H. A. M. El-Shibini etM. M. Motawi, Pharmazie, 24 (1969) 753.

    PubMed  Google Scholar 

  6. H. A. M. El-Shibini, S. Abd-Elfattah etM. M. Motawi, Pharmazie, 27 (1972) 570.

    PubMed  Google Scholar 

  7. N. S. Daabis, S. Abd-Elfattah etH. M. El-Banna, Pharmazie, 29 (1974) 400.

    PubMed  Google Scholar 

  8. J. Masse, R. Malaviolle, A. Chauvet etF. Sabon, Trav. Soc. Pharm., Montpellier 36 (1976) 169.

    Google Scholar 

  9. J. Masse, R. Malaviolle etA. Chauvet, Ann. Pharm. Fr. 34 (1976) 407.

    PubMed  Google Scholar 

  10. J. Masse etA. Chauvet, J. Thermal Anal., 14 (1978) 299.

    Google Scholar 

  11. W. MacCrone, Fusion Methods in Chemical Microscopy, Interscience New York, 1957.

    Google Scholar 

  12. J. Masse etF. Sabon, Bull. Soc. Pharm. Ouest, 16 (1974) 329.

    Google Scholar 

  13. S. S. Yang etJ. K. Guillory, J. Pharm. Sci. 61 (1972) 26.

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Faculté Pharmacie, Laboratoire de Chimie Générale et Minérale U. E. R. des Sciences Pharmaceutiques, 34000, Montpellier, France

    J. Masse, R. Malaviolle & A. Chauvet

Authors
  1. J. Masse
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. R. Malaviolle
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. A. Chauvet
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Masse, J., Malaviolle, R. & Chauvet, A. Etude des melanges binaires khelline-cafeine et khelline-sulfapyridine. Journal of Thermal Analysis 16, 123–135 (1979). https://doi.org/10.1007/BF01909639

Download citation

  • Received:

  • Revised:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01909639

Search

Navigation