Advertisement

Basic Research in Cardiology

, Volume 76, Issue 4, pp 449–452 | Cite as

The interaction of calcium and cAMP and the relationship to ventricular vulnerability

  • F. T. Thandroyen
  • L. M. Higginson
  • L. H. Opie
Original Contributions

Key words

Calcium cAMP catecholamine ventricular fibrillation protection 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Ceremuzynski, L., J. Staszewska-Barczak, K. Herbaczynska-Cedro: Cardiac rhythm disturbances and the release of catecholamines after acute coronary occlusion in dogs. Cardiovasc. Res.3, 190–197 (1969).PubMedGoogle Scholar
  2. 2.
    Corbalan, R., R. L. Verrier, B. Lown: Differing mechanisms for ventricular vulnerability during coronary artery occlusion and release. Amer. Heart J.92, 223–230 (1976).PubMedGoogle Scholar
  3. 3.
    Corr, P. B., F. X. Witkowski, B. E. Sobel: Mechanisms contributing to malignant dysrhythmias induced by ischaemia in the cat. J. Clin. Invest.61, 109–119 (1978).PubMedGoogle Scholar
  4. 4.
    Jewitt, D. E., D. Reid, M. Thomas, C. J. Mercer, C. Valori, J. P. Shillingford: Free noradrenaline and adrenaline excretion in relation to the development of cardiac arrhythmias and heart failure in patients with acute myocardial infarction. Lancet1969/I, 635–641.Google Scholar
  5. 5.
    Kannegiesser, G. J., W. F. Lubbe, L. H. Opie: Experimental myocardial infarction with left ventricular failure in the isolated perfused rat heart: Effects of isoproterenol and pacing. J. Molec. Cell. Cardiol.7, 135–151 (1975).CrossRefGoogle Scholar
  6. 6.
    Lubbe, W. F., T. Podzuweit, P. S. Daries, L. H. Opie: The role of cyclic adenosine monophosphate in adrenergic effects on ventricular vulnerability to fibrillation in the isolated perfused rat heart. J. Clin. Invest.61, 1260–1269 (1978).PubMedGoogle Scholar
  7. 7.
    Podzuweit, T., A. J. Dalby, G. W. Cherry, L. H. Opie: Cyclic AMP levels in ischaemic and non-ischaemic myocardium following coronary artery ligation: Relation to ventricular fibrillation. J. Molec. Cell. Cardiol.10, 81–94 (1978).CrossRefGoogle Scholar
  8. 8.
    Podzuweit, T., W. F. Lubbe: Relation between post-ligation arrhythmias and myocardial cAMP in the pig. J. Molec. Cell. Cardiol.9, 40 (1977).Google Scholar
  9. 9.
    Podzuweit, T., W. F. Lubbe, L. H. Opie: Cyclic AMP, ventricular fibrillation and antiarrhythmic drugs. Lancet1976/I, 341–342.Google Scholar
  10. 10.
    Schaal, S. F., A. G. Wallace, W. S. Sealy: Protective influence of cardiac denervation against arrhythmias of myocardial infarction. Cardiovasc. Res.3, 241–244 (1969).PubMedGoogle Scholar
  11. 11.
    Vetter, N. J., R. C. Strange, W. Adam, M. F. Oliver: Initial metabolic and hormonal response to acute myocardial infarction. Lancet1974/I, 284–288.Google Scholar
  12. 12.
    Wollenberger, A., O. Ristau, G. Schoffa: Eina einfache Technik der extrem schnellen Abkühlung gröberer Gewebestücke. Pflüg. Arch.270, 399–412 (1960).CrossRefGoogle Scholar
  13. 13.
    Thandroyen, F.: Protective action of calcium anatagonist agents against ventricular fibrillation in the isolated perfused rat heart. J. Molec. Cell. Cardiol. (in press).Google Scholar

Copyright information

© Dr. Dietrich Steinkopff Verlag 1981

Authors and Affiliations

  • F. T. Thandroyen
    • 1
  • L. M. Higginson
    • 1
  • L. H. Opie
    • 1
  1. 1.MRC Ischaemic Heart Disease Research Unit, Department of MedicineGroote Schuur Hospital and University of Cape TownSouth Africa

Personalised recommendations