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Linear relationship between perfusion area and infarct size

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Summary

The purpose of this study was to develop a technique measuring the perfusion area of the coronary artery preocclusively and to study the relationship between the perfusion are aand infarct size.125I tracer microspheres were selectively injected into the left circumflex coronary artery (LCX) preocclusively, and then the LCX was ligated 48 hours later the heart was removed, rapidly frozen, and 50-μ transverse sections were obtained from base, middle and apex of the canine left ventricle, and used for autoradiography to measure perfusion area and for tetrazolium staining to measure infarct size. Dogs were divided into 2 groups: group 1 in which the main trunk of the LCX was occluded to produce large infarct (n=10) and group 2 in which the distal branch of the LCX was occluded to produce small infarct (n=10). There was a linear correlation between the perfused and infarcted area regardless of a size or location of the perfusion area involved. These results indicate that the extent of infarction is directly proportional to the perfusion area and is not altered by the location in the ventricle.

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Author notes

  1. M. Nakamura M.D. (Professor and Director)

    Present address: Research Institute of Angiocardiology and Cardiovascular Clinic, Kyushu University Medical School, 3-1-1 Maidashi, Higashi-ku, 812, Fukuoka, Japan

Authors and Affiliations

  1. Research Institute of Angiocardiology and Cardiovascular Clinic, Kyushu University Medical School, 3-1-1 Maidashi, Higashi-ku, 812, Fukuoka, Japan

    H. Tomoike, K. Sakai, H. Ootsubo & Y. Kikuchi

Authors
  1. M. Nakamura M.D.
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  2. H. Tomoike
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  3. K. Sakai
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  4. H. Ootsubo
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  5. Y. Kikuchi
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Additional information

This project was supported by Grant-in-Aid for Scientific Research (Nos. 344044 and 544049), Encouragement of Young Scientists (No. 477399) and Special Project Research (No. 412009) from Ministry of Education, Science and Culture, Japan.

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Nakamura, M., Tomoike, H., Sakai, K. et al. Linear relationship between perfusion area and infarct size. Basic Res Cardiol 76, 438–442 (1981). https://doi.org/10.1007/BF01908338

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