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Transmural gradients in myocardial metabolic rate

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Summary

To examine the 2-deoxyglucose (2-DG)-method for myocardial tissue, glucose uptake was measured directly and via the 2-DG-technique in 16 isolated perfused guinea pig hearts. A correlation (r=0.7; p<0.01) between both methods was found. In the in situ working canine heart 2-DG revealed a 20% higher glucose uptake of the subendocardial layers as compared with the subepicardial. Blood flow to these layers, estimated by albumin aggregates, exceeded that to the subepicardial by 82%. Thoracotomy resulted in a homogeneous distribution of blood flow and tissue PO2, comparable to a homogeneous distribution of glucose uptake in isolated perfused hearts.

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Author notes

  1. W. Breull

    Present address: Dept. of Physiol, Univ. Bonn, 5300, Bonn, FRG

Authors and Affiliations

  1. Dept. of Physiol, Univ. Bonn, 5300, Bonn, FRG

    H. Flohr, S. Schuchardt & H. Dohm

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  1. W. Breull
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  2. H. Flohr
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  3. S. Schuchardt
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  4. H. Dohm
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Additional information

With technical assistance of B. Schreiber and Ch. Pusch.

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Breull, W., Flohr, H., Schuchardt, S. et al. Transmural gradients in myocardial metabolic rate. Basic Res Cardiol 76, 399–403 (1981). https://doi.org/10.1007/BF01908331

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  • DOI: https://doi.org/10.1007/BF01908331

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