Summary
During open heart surgery, needle biopsy material was obtained in four patients, and electron microscopic preparations of the mitochondrial ATPases (coupling factors 1) in human myocardial cells were performed.
The pre-ischemic, normal structure of the mitochondrial ATPases and the changes which occur during the ischemic interval were described. An increase in the center-to-center space was shown in the post-ischemic phase. This result was discussed for the pathogenesis of subcellular injuries due to ischemia.
Zusammenfassung
Während Operationen am offenen Herzen wurden bei vier Patienten Myokardbiopsien durchgeführt. Die Biopsien wurden zur elektronenmikroskopischen Darstellung der mitochondrialen ATPasen (coupling factors 1) aufgearbeitet.
Die präischänische Normalstruktur der mitochondrialen ATPasen und deren Veränderungen während Ischämie werden beschrieben. Dabei zeigt sich postischämisch eine Vergrößerung der Zentrum-Zentrum-Abstände.
Diese ultrastrukturellen Ergebnisse werden im Hinblick auf ihre Bedeutung für die Pathogenese der subzellulären Schäden erörtert.
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Beyersdorf, F., Gauhl, C., Elert, O. et al. Electron microscopic visible ischemic changes of the mitochondrial ATPases in human myocardial cells during extracorporal circulation. Basic Res Cardiol 76, 106–113 (1981). https://doi.org/10.1007/BF01908166
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DOI: https://doi.org/10.1007/BF01908166