Summary
The study was carried out in 13 mongrel dogs. Regional myocardial blood flow was measured using radiolabelled microspheres. Lactate, H+-ions, and O2 content were measured in arterial and local venous blood. Partial occlusion of the ramus circumflexus (LCX) led to a decrease in left ventricular dp/dt max, systemic arterial pressure, and a marked release of lactate from the underperfused myocardium. With DHE (2 μg/kg infused within 5 min, 8 dogs), a slight decrease in heart rate, left ventricular dp/dt max, LCX-resistance and a small increase in femoral and total peripheral resistance as well as in arterial and left and right atrial pressure was observed. In the normally perfused and in the underperfused part of the left ventricle microsphere assessed blood flow was unchanged or slightly elevated with DHE. Lactate release from the underperfused myocardium was markedly reduced. None of the DHE-induced effects on hemodynamic and metabolic parameters were observed in control experiments with infusion of 0.9% NaCl (5 ml). The results indicate that DHE leads to an amelioration of impaired metabolism in the underperfused myocardium and exerts no vasoconstriction in this area.
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References
Aellig WH, Berde B (1969) Studies of the effect of natural and synthetic polypeptide type ergot compounds on a peripheral vascular bed. Brit J Pharm 36:561–570
Barcroft H, Konzett H, Swan HJC (1951) Observations on the action of the hydrogenated alkaloids of the ergotoxine group on the circulation in man. J Physiol 112:273–291
Bevegard S, Castenfors J, Lindblad LE (1974) Hemodynamic effects of dihydroergotamine in patients with postural hypotension. Acta med scand 196:473–477
Chu D, Stuermer E (1973) Studies on the mechanism of action of dihydroergotamine (DHE) on the vascular bed of cat skeletal muscle. Brit J Pharmacol 48:331P-332P
De Vleeschhouwer GR (1949) On the pharmacology of dihydroergotamine. Arch int pharmakodyn 73:461–473
Haddy FS, Campell GS (1953) Pulmonary vascular resistance in anaesthetized dogs. Amer J Physiol 172:747–751
Hales JRS (1974) Radioactive microsphere techniques for studies of the circulation. Clin Exp Pharmacol Physiol Suppl 1:31–46
Halmagy D, Ivanyi J, Felkai B, Zsoter T, Tenyi M, Szücs Zs (1953) The effect of dihydroergotamine and hydergin on pulmonary arterial pressure in man. Scand J clin Invest 5:85–89
Harris P, Bishop JM, Segel N (1963). The effects of dihydroergotamine tartrate on the pulmonary and systemic circulation in man. Clin Sci 25:443–447
Hohorst HJ (1970) Bestimmung von L-(+)-Lactat mit Lactatdehydrogenase und NAD. In: Methoden der enzymatischen Analyse, vol II, Verlag Chemie, Weinheim, pp 1425–1429
Kennedy BL, Ellis S (1969) Interactions of catecholamines and adrenergic blocking agents at receptor sites mediating glycogenolysis in the rat. Arch int Pharmacodyn 177:390–406
Krüger K, Neff K (1973) Dihydroergotamine in the treatment of orthostatic circulatory disorders: a double-blind comparison with placebo. J Med 4:106–117
Mellander S, Nordenfeldt I (1970) Comparative effects of dihydroergotamine and noradrenaline on resistance, exchange and capacitance functions in the peripheral circulation. Clin Sci 39:183–201
Mostbeck A, Partsch H (1978) Umverteilung regionaler Blutvolumina durch Dihydroergotamin und Beinkompression. Med Klin 73:801–806
Müller-Schweinitzer E (1974) Studies in the peripheral mode of action of dihydroergotamine in human and canine veins. Eur J Pharmacol 27:231–237
Nordenfeldt I, Mellander S (1972) Central hemodynamic effects of dihydroergotamine in patients with orthostatic hypotension. Acta med scand 191:115–120
Raberger G, Schütz W, Binder JP, Stanek B (1978) Regional changes in myocardial metabolism induced by constriction of the circumflex branch of the left coronary artery. Artery 4:157–166
Raberger G, Schwarz M, Benke T, Kraupp O (1981) Die Wirkung von Dihydroergotamin auf den großen und kleinen Kreislauf. Postoperat Thromboemb-Prophyl, Georg Thieme Verlag, Stuttgart New York
Rothlin E (1974) The pharmacology of the natural and dihydrogenated alkaloids of ergot. Bull Schweiz Akad med Wiss 2:249–273
Sàxena PR, Cairo-Rawlins WI (1979) Presynaptic inhibition by ergotamine of the responses to cardioaccelerator nerve stimulation in the cat. Eur J Pharmacol 58:305–312
Stuermer E (1976) Pharmacological basis of the treatment of orthostatic disorders with ergot alkaloids. Cardiol 61:(Suppl)290–301
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This work was supported by the “Fonds zur Förderung der wissenschaftlichen Forschung”.
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Seitelberger, R., Schütz, W. & Raberger, G. Effects of dihydroergotamine (DHE) on blood flow and metabolism in the underperfused myocardium in anaesthetized dogs. Basic Res Cardiol 79, 461–468 (1984). https://doi.org/10.1007/BF01908147
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DOI: https://doi.org/10.1007/BF01908147