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Left ventricular end-systolic pressure-volume relationships as a measure of ventricular performance

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Summary

The extent to which conclusions about myocardial performance may be drawn from end-systolic pressure-volume relations was investigated. Left ventricular isovolumetric and end-systolic pressure-volume relationships were measured in the rat, under acute impairment of contractility (hexobarbital), at chronic pressure overload (spontaneously hypertensive rats), and at chronic volume overload (aortocaval shunt). Our results confirm the classic conception of Otto Frank where the curves of the isovolumetric maxima and the curves of the end-systolic pressure-volume relations follow separate courses. Acute alterations in contractility can be detected from shifts in the end-systolic pressure-volume relations. In chronic pressure or volume overloaded hearts the end-systolic pressure-volume relations do not render conclusions about ventricular or myocardial performance since in chronically altered hearts, the course of the end-systolic pressure-volume relations is primarily influenced by geometric factors.

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Author notes

  1. G. Kissling

    Present address: Physiological Institute II, University of Tübingen, D-7400, Tübingen, West Germany

  2. N. Takeda

    Present address: Department of Internal Medicine, Aoto Hospital, Jikei University, Tokyo, Japan

Authors and Affiliations

  1. Physiological Institute II, University of Tübingen, D-7400, Tübingen, West Germany

    N. Takeda & M. Vogt

Authors
  1. G. Kissling
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  2. N. Takeda
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  3. M. Vogt
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Additional information

Dedicated to Professor R. Jacob on the occasion of his 60th birthday.

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Kissling, G., Takeda, N. & Vogt, M. Left ventricular end-systolic pressure-volume relationships as a measure of ventricular performance. Basic Res Cardiol 80, 594–607 (1985). https://doi.org/10.1007/BF01907858

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  • DOI: https://doi.org/10.1007/BF01907858

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