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Screening of heart-arrhythmic and anti-arrhythmic drugs in the male albino rat

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Summary

The technique of screeing heart anti-arrhythmic drugs in the rat is described. A stable arrhythmia can be best produced by intravenous injection of Barium chloride, Strophantin and Aconitin. The response to other arrhythmic substances like Lanatoside C or Adrenaline is more irregular. The potential anti-arrhythmic effect of some solvents, used in the preparation of injectable solutions, is stressed.

Zusammenfassung

Die Technik der Prüfung potentiell antiarrhythmischer Substanzen an männlichen Albinoratten wird im einzelnen beschrieben. Eine “stabile” Arrhythmie läßt sich am sichersten durch intravenöse Verabreichung von Bariumchlorid, Strophantin G oder Akonitin erzeugen, während Lanatosid C oder Adrenalininjektionen bei der Ratte eine weniger regelmäßige Wirkungsstärke hinsichtlich der Intensität und Dauer der durch sie erzeugten kardialen Arrhythmie aufweisen. Bei der Prüfung handelsüblicher Substanzen in Ampullenform ist ein möglicher antiarrhythmischer Effekt des Lösungsmittels in Betracht zu ziehen.

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References

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Author notes

  1. F. W. Eichbaum

    Present address: Terapêutica Clínica do Departamento de Clínica Médica da Faculdade de Medicina da Universidade de Saõ Paulo, (Brasil)

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    1. F. W. Eichbaum
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    With 4 figures and 1 table

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    Eichbaum, F.W. Screening of heart-arrhythmic and anti-arrhythmic drugs in the male albino rat. Basic Res Cardiol 68, 73–79 (1973). https://doi.org/10.1007/BF01907657

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    • DOI: https://doi.org/10.1007/BF01907657

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