Basic Research in Cardiology

, Volume 74, Issue 5, pp 555–567 | Cite as

Influence of verapamil on cellular integrity and electrolyte concentrations of ischemic myocardial tissue in the cat

  • A. M. Lefer
  • E. W. Polansky
  • C. P. Bianchi
  • S. Narayan
Original Contributions


Verapamil, at a dose of 1 mg/kg, was given intravenously to anesthetized cats one hour after coronary artery occlusion. Verapamil significantly reduced mean arterial blood pressure, but produced an increase in heart rate, partially offsetting the reduction in myocardial oxygen demand resulting from the reduction in pressure. Verapamil failed to prevent the elevations in the S-T segment of the electrocardiogram observed in cats subjected to myocardial ischemia (MI) and given only the vehicle for verapamil (i.e., 0.9% NaCl). Moreover, verapamil also did not prevent the accumulation of creatine phosphokinase (CPK) activity in the circulating blood after MI. Nevertheless, verapamil significantly prevented the loss in CPK and in amino-nitrogen observed in the ischemic region of the myocardium, indicating some protective effect on myocardial integrity. The major effects of verapamil on electrolyte content of ischemic myocardial tissue were a decrease in sodium and an increase in potassium. However, calcium gain by the heart was not prevented by verapamil. Verapamil, therefore, exerts a partial degree of protection of the ischemic myocardium but exerts some other effects which do not help prevent the spread of ischemic damage in the myocardium.


Creatine Verapamil Creatine Phosphokinase Coronary Artery Occlusion Ischemic Region 
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Der Einfluß von Verapamil auf zelluläre Integrität und Elektrolytkonzentration des ischämischen Myokardgewebes der Katze


Eine Stunde nach Koronarokklusion wurde anästhesierten Katzen Verapamil (1 mg/kg) intravenös verabreicht. Verapamil reduzierte den mittleren arteriellen Blutdruck signifikant, bewirkte jedoch eine Zunahme der Herzfrequenz, was teilweise einer Reduktion des myokardialen Sauerstoffbedarfs infolge der Druckabnahme entgegenwirkte. Verapamil konnte Anhebungen des ST-Segmentes im Ekg nicht verhindern, verglichen mit Experimenten, in welchen Katzen mit myokardialer Ischämie lediglich das Lösungsmittel für Verapamil (d. h. 0,9% NaCl) appliziert wurde. Auch konnte Verapamil den Anstieg der Kreatinphosphokinase-Aktivität als Folge einer myokardialen Ischämie nicht verhindern. Dennoch verhütete Verapamil einen Verlust von CPK und Aminostickstoff des ischämischen Myokards signifikant, was für einen gewissen Schutzeffekt bezüglich der myokardialen Unversehrtheit spricht. Die wesentlichen Effekte von Verapamil auf den Elektrolytgehalt des ischämischen Myokardgewebes waren eine Abnahme des Natrium-und eine Zunahme des Kaliumgehaltes. Die Zunahme des Calciums wurde durch Verapamil jedoch nicht verhütet. Die Ergebnisse zeigen, daß Verapamil in gewissem Maß einen Schutzeffekt für ischämisches Myokard besitzt, jedoch einige andere Effekte zeigt, die nicht dazu beitragen, das Ausmaß des ischämischen Myokardschadens zu begrenzen.


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Copyright information

© Dr. Dietrich Steinkopff Verlag 1979

Authors and Affiliations

  • A. M. Lefer
    • 1
    • 2
  • E. W. Polansky
    • 1
    • 2
  • C. P. Bianchi
    • 1
    • 2
  • S. Narayan
    • 1
    • 2
  1. 1.Department of Physiology, Jefferson Medical CollegeThomas Jefferson UniversityPhiladelphiaUSA
  2. 2.Department of Pharmacology, Jefferson Medical CollegeThomas Jefferson UniversityPhiladelphiaUSA

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