Summary
The relationship between the collateral perfusion of ischemic myocardium and the size of the ischemic zone was examined in open-chest anesthetized dogs. Proximal and distal segments of the left anterior descending coronary artery were cannulated and perfused extracorporally from the carotid artery. By occluding one or both of these perfusion lines, three different sized ischemic zones were made in each heart. Collateral perfusion to each ischemic zone was measured by the133Xe washout method. Blood flow density (flow per unit volume tissue) to the ischemic zone was lowest when both coronary segments were occluded, as opposed to occluding either single segment in each heart (0.17±0.03 vs. 0.28±0.005 ml/min/cm3, p<0.01 by the paired t-test). A significant correlation could not be demonstrated between the ischemic zone size and the collateral flow when the data from all dogs were pooled (r=0.19, p>0.05). These findings demonstrate that collateral perfusion of ischemic myocardium is inversely related to ischemic zone size in any given heart, but ischemic zone size is actually a minor determinant of collateral flow when compared to the large individual variability of coronary collateralization present in the dog population.
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References
Reimer KA, Jennings RB (1979) The wavefront phenomenon of myocardial ischemic cell death. II. Transmural progression of necrosis within the framework of ischemic bed size (myocardium at risk) and collateral flow. Lab Invest 40:633–644
Reimer KA, Jennings RB, Cobb FR, Murdock RH, Greenfield JC, Becker LC, Bulkley BH, Hutchins GM, Schwartz RP Jr, Bailey KR, Passamani ER (1985) Animal models for protecting ischemic myocardium: Results of the NHLBI cooperative study. Comparison of unconscious and conscious dog models. Circ Res 56:651–665
Miura T, Yellon DM, Hearse DJ, Downey JM (1987) Determinants of myocardial infarct size during permanent coronary occlusion in the closed chest dog. J Am Coll Cardiol 9:647–654
Rivas F, Cobb FR, Bache RJ, Greenfield JC (1976) Relationship between blood flow to ischemic regions and the extent of myocardial infarction. Serial measurement of blood flow to ischemic regions in dogs. Circ Res 38:429–447
Schaper W (editor) (1979) The pathophysiology of myocardial perfusion. Elsevier/North Holland; p 362
Jugdutt BI, Hutchins GM, Bulkley BH, Becker LC (1979) Myocardial infarction in the conscious dog: Three-dimensional mapping of infarct, collateral flow and region at risk. Circulation 60:1141–1150
Schaper W (1978) Experimental coronary artery occlusion. III. The determinants of collateral blood flow in acute coronary occlusion. Basic Res Cardiol 73:584–590
Reimer KA, Ideker RE, Jennings RB (1981) Effect of coronary occlusion site on ischemic bed size and collateral blood flow in dogs. Cardiovasc Res 15:668–674
Gumm DC, Barnes D, Thompson S, Marcus ML, Harrison DG (1984) Native collateral resistance is dependent on risk area size. Circulation 70 (Suppl II)II-227
Patterson RE, Kirk ES (1980) Apparent improvement in canine collateral myocardial blood flow during vasodilation depends on criteria used to identify ischemic myocardium. Circ Res 47:108–116
Downey JM, Rindsberg D, Isherwood W (1985) Easy interfacing projects for the commodore 64. Prentice-Hall, New York
Flameng W, Wusten B, Winkler B, Pasyk S, Schaper W (1975) Influence of perfusion pressure and heart rate on local myocardial flow in the collateralized heart with chronic coronary occlusion. Am Heart J 89:51–59
Kety SS, Schmidt CF (1948) The nitrous oxide method for the quantitative determination of cerebral blood flow in man. Theory procedure and normal values. J Clin Invest 27:476–483
Yoshida S, Akizuki S, Gowski D, Downey JM (1985) Discrepancy between microsphere and diffusible tracer estimates of perfusion to ischemic myocardium. Am J Physiol 249:H255-H264
Conn HL Jr (1961) Equilibrium distribution of radioxenon in tissue. Xenon-hemoglobin association curve. J Appl Physiol 16:1065–1070
Downey JM, Yoshida S, Harpen M (1986) A functional estimate of overlap between adjacent coronary circulations in the dog. Basic Res Cardiol 81:336–341
Bloor C (1974) Functional significance of coronary collateral circulation. Am J Pathol 1974; 76:562–587
Koyangi S, Eastham CL, Harrison DG, Marcus ML (1982) Transmural variation in the relationship between myocardial infarct size and risk area. Am J Physiol 242:H867-H874
Lowe JE, Reimer KA, Jennings RB (1978) Experimental infarct size as a function of the amount of myocardium at risk. Am J Path 90:363–380
Melin JA, Becker LC (1983) Salvage of ischemic myocardium by prostacyclin during experimental myocardial infarction. J Am Coll Cardiol 2:279–286
Downey JM, Chagrasulis RW (1976) The effect of cardiac contraction on collateral resistance in the canine heart. Circ Res 39:797–800
Kattus AA, Greg DE (1959) Some determinants of coronary collateral flow in the open-chest dog. Circ Res 7:628
Schaper W (editor) (1971) The collateral circulation of the heart. Elsevier/North Holland, Amsterdam, p.31
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Miura, T., Downey, J.M. Collateral perfusion of ischemic myocardium is inversely related to the size of the ischemic zone. Basic Res Cardiol 83, 128–136 (1988). https://doi.org/10.1007/BF01907266
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DOI: https://doi.org/10.1007/BF01907266