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Epicardial ECG signals following global myocardial ischaemia

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Summary

Experiments were performed on 10 dog hearts undergone 15 to 90-minute normothermic arrests and 60-minute reperfusion in a special heart-lung model. The purpose of the experiments was to characterize the global ischaemic effects recorded on epicardial electrograms. The duration of QRS complexes and of RR intervals, the integral of ST segment shifts (σST), the number of points showed ST segment displacements (NoST) and the ST segment isopotential map obtained by computer control were evaluated. Only a minor ST segment deviation, a small increase in duration of QRS complexes and of RR intervals with bradycardia and a tendency to electrical stability were found after global ischaemic influences. These observations indicate that pathological electrical manifestations occurring after a global ischaemia are less serious than those occurring after a focal ischaemia.

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References

  1. Braunwald, E., P. R. Maroko: ST-segment mapping. Realistic and unrealistic expectations. Circulation54, 529–532 (1976).

    PubMed  Google Scholar 

  2. Cox, J. L., T. M. Daniel, J. P. Boineau: The electrophysiologic time course of acute myocardial ischemia and the effect of early coronary artery reperfusion. Circulation48, 971–983 (1973).

    PubMed  Google Scholar 

  3. Elharrar, V., P. R. Foster, T. L. Jirak, W. E. Gaum, D. P. Zipes: Alterations in canine myocardial excitability during ischemia. Circulat. Res.40, 98–105 (1977).

    PubMed  Google Scholar 

  4. Fozzard, H. A., D. S. DasGupta: ST segment potentials and mapping. Circulation54, 533–537 (1976).

    PubMed  Google Scholar 

  5. Friedman, P. L., J. R. Stewart, J. J. Fenoglio Jr., A. L. Wit: Survival of subendocardial Purkinje fibers after extensive myocardial infarction in dogs. Circulat. Res.33, 597–611 (1973).

    PubMed  Google Scholar 

  6. Harris, A. S.: Potassium and experimental coronary occlusion. Amer. Heart J.71, 797–802 (1966).

    PubMed  Google Scholar 

  7. Hearse, D. J.: Reperfusion of the ischaemic myocardium. J. Mol. Cell. Cardiol.9, 605–616 (1977).

    PubMed  Google Scholar 

  8. Holland, R. P., H. Brooks: TQ-ST segment mapping: critical review and analysis of current concepts. Amer. J. Cardiol.40, 110–129 (1977).

    PubMed  Google Scholar 

  9. Jennings, R. B.: Relationship of acute ischemia to functional defects and irreversibility. Circulation53, Suppl. 1. 26–29 (1976).

    Google Scholar 

  10. Lazar, H. L., G. D. Buckberg, A. J. Manganaro, H. Becker, J. V. Maloney: Reversal of ischemic damage with amino acid substrate enhancement during reperfusion. Surgery88, 702–709 (1980).

    PubMed  Google Scholar 

  11. Lazzara, R., N. El-Sherif, B. J. Scherlag: Electrophysiological properties of canine Purkinje cell in one-day-old myocardial infarction. Circulation33, 722–734 (1973).

    Google Scholar 

  12. Maroko, P. R., J. K. Kjekshus, B. E. Sobel, T. Watanabe, J. W. Covell, J. Ross, E. Braunwald: Factors influencing infarct size following experimental coronary artery occlusions. Circulation43, 67–82 (1971).

    PubMed  Google Scholar 

  13. Mezey, B., I. Juricskai, T. Simor, S. Szabados, E. Röth, Gy. Temes, B. Török: Electrocardiological evaluation of regional ischemia in dogs (in press).

  14. Ross, J.: Electrocardiographic ST-segment analysis in the characterization of myocardial ischemia and infarction. Circulation53, Suppl. 1 73–81 (1976).

    Google Scholar 

  15. Ruf, W., G. T. Smith, G. Geary, V. Pressler, R. J. Anema, A. Suehiro, J. J. McNamara: Effect of left ventricular-to-aortic bypass on infarct size and infarct microcirculation in baboons. J. Thorac. Cardiovasc. Surg.81, 408–418 (1981).

    PubMed  Google Scholar 

  16. Ruffy, R., D. E. Lovelace, Th. M. Mueller, S. G. Koebel, D. P. Zipes: Relationship between changes in left ventricular bipolar electrograms and regional myocardial blood flow during acute coronary artery occlusion in the dog. Circulat. Res.45, 764–770 (1979).

    PubMed  Google Scholar 

  17. Schneider, J. A., N. Speralakis: The demonstration of energy dependence of the isoproterenol-induced transcellular Ca2+ current in isolated perfused guinea pig hearts — an explanation for mechanical failure of ischaemic myocardium. J. Surg. Res.16, 389–403 (1974).

    PubMed  Google Scholar 

  18. Speralakis, N., L. Belardinelli, S. M. Vogel: Electrophysiological aspects during myocardial ischemia. Proc. VIII. World Congr. Cardiol. Int. Congr. Series470, 229–236 (1978).

    Google Scholar 

  19. Surawicz, B.: The disputed ST segment mapping: is the technique ready for wide application in practice? Amer. J. Cardiol.40, 137–140 (1977).

    PubMed  Google Scholar 

  20. Török, B., E. Röth, K. Trombitás: Ultrastructural changes of the subendocardium in ischemic and cardioplegic states before and after reperfusion. Eur. Surg. Res.14, 17–26 (1982).

    PubMed  Google Scholar 

  21. Török, B., I. Tóth: Fibrillationsschwellenmessung an normalen Hundeherzen und nach akuter Deszendens-Ligatur. Thoraxchirurgie16, 227–234 (1968).

    Google Scholar 

  22. Török, B., K. Trombitás, E. Röth: Ultrastructural sequences following reperfusion of ischemic myocardium. Acta morph. Acad. Sci. hung. (in press).

  23. Trump, B. F., W. J. Mergner, M. W. Kahng, A. J. Saladino: Studies on the subcellular pathophysiology of ischemia. Circulation53, Suppl. 1. 17–26 (1976).

    Google Scholar 

  24. Weiss, J., K. I. Shine: Extracellular potassium accumulation during myocardial ischaemia: implications for arrhythmogenesis. J. Mol. Cell. Cardiol.13, 699–704 (1981).

    PubMed  Google Scholar 

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Author notes

  1. B. Török

    Present address: Department of Experimental Surgery-Intensive Therapy, University Medical School, Pécs, Hungary

Authors and Affiliations

  1. Department of Experimental Surgery-Intensive Therapy, University Medical School, Pécs, Hungary

    E. Röth, B. Mezey, S. Szabados & T. Simor

  2. Department of Anesthesiology-Intensive Therapy, University Medical School, Pécs, Hungary

    B. Török, E. Röth, B. Mezey, S. Szabados & T. Simor

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  1. B. Török
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  2. E. Röth
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  3. B. Mezey
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  4. S. Szabados
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Török, B., Röth, E., Mezey, B. et al. Epicardial ECG signals following global myocardial ischaemia. Basic Res Cardiol 78, 593–600 (1983). https://doi.org/10.1007/BF01907205

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  • DOI: https://doi.org/10.1007/BF01907205

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