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Adaptation to stress exposure prevents arrhythmogenic and contractural effects of the excess of Ca2+ on the heart by the increased activity of sarcoplasmic reticulum

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Summary

Adaptation of rats to repcated short-term stress exposure prevents, to a considerable extent, contractural and arrhythmogenic effects of high concentrations of extracellular Ca2+ on isolated heart. Increased efficiency of SR Ca2+-pump functioning and a significant increase in Ca2+ pump resistance to autolysis are proved to play the main role in this effect.

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Author notes

  1. F. Z. Meerson

    Present address: Institute of General Pathology and Pathological Physiology of the USSR AMS, Baltijskaya 8, 125315, Moscow, USSR

Authors and Affiliations

  1. Institute of General Pathology and Pathological Physiology of the USSR AMS, Baltijskaya 8, 125315, Moscow, USSR

    I. Yu. Malyshev & T. G. Sazontova

Authors
  1. F. Z. Meerson
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  2. I. Yu. Malyshev
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  3. T. G. Sazontova
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Meerson, F.Z., Malyshev, I.Y. & Sazontova, T.G. Adaptation to stress exposure prevents arrhythmogenic and contractural effects of the excess of Ca2+ on the heart by the increased activity of sarcoplasmic reticulum. Basic Res Cardiol 85, 96–103 (1990). https://doi.org/10.1007/BF01907018

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  • DOI: https://doi.org/10.1007/BF01907018

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